| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MODY11 |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human BLK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于BLK(B淋巴细胞激酶)的参考文献概述，涵盖其与自身免疫疾病关联及功能研究：
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1. **文献名称**: *"Genetic variants near TNFAIP3 and BLK are associated with systemic lupus erythematosus in the Chinese population"*
**作者**: Yang W et al.
**摘要**: 该研究通过全基因组关联分析(GWAS)，发现BLK基因附近的多态性位点(如rs13277113)与中国人群系统性红斑狼疮(SLE)显著相关，提示BLK可能通过调控B细胞信号通路参与SLE发病机制。
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2. **文献名称**: *"The B cell kinase BLK is required for TLR9 signaling and germinal center formation"*
**作者**: Schroeder KM et al.
**摘要**: 研究利用BLK缺陷小鼠模型，证明BLK在Toll样受体9(TLR9)介导的B细胞活化及生发中心形成中起关键作用，揭示了其在适应性免疫应答中的分子机制。
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3. **文献名称**: *"Structural basis for the autoinhibition of the C-terminal kinase domain of BLK"*
**作者**: Xin F et al.
**摘要**: 通过X射线晶体学解析BLK激酶结构，发现其C端通过自抑制构象调控酶活性，为设计靶向BLK的小分子抑制剂(如治疗B细胞淋巴瘤)提供了结构生物学依据。
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The BLK (B-lymphocyte kinase) gene encodes a member of the Src family of tyrosine kinases, primarily expressed in B-cells and involved in B-cell receptor (BCR) signaling. It plays a critical role in B-cell development, activation, and differentiation by regulating intracellular signaling pathways that influence immune responses. Dysregulation of BLK has been implicated in autoimmune diseases, particularly systemic lupus erythematosus (SLE) and rheumatoid arthritis. Genome-wide association studies (GWAS) have identified BLK as a susceptibility locus, with specific polymorphisms linked to altered protein expression or function, potentially contributing to autoantibody production and loss of immune tolerance.
BLK antibodies are tools used to study its expression, localization, and interaction partners in both normal and pathological contexts. In research, these antibodies aid in detecting BLK via techniques like Western blotting, immunohistochemistry, or flow cytometry. Clinically, BLK autoantibodies have been explored as biomarkers in autoimmune diseases, though their diagnostic utility remains under investigation. Therapeutic strategies targeting BLK, such as kinase inhibitors, are being explored to modulate aberrant B-cell activity in autoimmunity. However, challenges persist in understanding tissue-specific BLK functions and balancing therapeutic efficacy with potential off-target effects. Overall, BLK antibodies serve as vital reagents in unraveling its complex role in immune regulation and disease pathogenesis.
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