| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BTF2; BT2.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human BTN2A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BTN2A2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "BTN2A2 regulates γδ T cell-mediated antitumor immunity"
**作者**: Arnett HA et al.
**摘要**: 该研究揭示了BTN2A2通过与γδ T细胞受体相互作用，调控其对肿瘤细胞的识别和杀伤功能。通过抗体阻断实验证明，抑制BTN2A2可增强γδ T细胞的抗肿瘤活性，提示其作为癌症免疫治疗靶点的潜力。
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2. **文献名称**: "Structural insights into BTN2A2 and BTN3A1 complex formation in butyrophilin-mediated immune signaling"
**作者**: Yang Y et al.
**摘要**: 通过X射线晶体学解析了BTN2A2与BTN3A1的复合物结构，揭示了二者在免疫信号中的协同作用。研究利用特异性抗体验证了二者结合的关键表位，为开发靶向BTN2A2/3A1通路的治疗性抗体提供了结构基础。
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3. **文献名称**: "BTN2A2 expression correlates with immune evasion in triple-negative breast cancer"
**作者**: Smith JR et al.
**摘要**: 分析三阴性乳腺癌样本发现，BTN2A2高表达与肿瘤微环境中T细胞浸润减少及患者预后不良相关。使用抗BTN2A2抗体阻断其功能后，可逆转免疫抑制表型，表明其在肿瘤免疫逃逸中的关键作用。
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**备注**：以上文献为示例，实际文献需通过PubMed或Google Scholar检索确认。建议结合关键词“BTN2A2 antibody”、“immune regulation”或“γδ T cells”获取最新研究。
The BTN2A2 (Butyrophilin Subfamily 2 Member A2) antibody targets a protein belonging to the butyrophilin family, which plays roles in immune regulation and cell signaling. BTN2A2 is a transmembrane protein characterized by immunoglobulin (Ig)-like domains and is expressed in various tissues, including immune cells and epithelial surfaces. It has gained attention for its potential involvement in modulating γδ T cell responses, particularly through interactions with phosphoantigens and other butyrophilin family members like BTN3A1. These interactions are critical for immune surveillance, especially in detecting cellular stress or malignant transformation.
Research suggests BTN2A2 may influence immune tolerance, inflammation, and antitumor immunity. Its dysregulation has been implicated in autoimmune diseases, cancers, and infections. For instance, BTN2A2 may suppress excessive immune activation in autoimmune conditions, while in cancer, altered expression could affect tumor immune evasion. Antibodies against BTN2A2 are primarily used as research tools to study its function, localization, and interactions. Therapeutic applications are exploratory, with efforts focused on leveraging its immunomodulatory properties for cancer immunotherapy or autoimmune therapies. However, the precise mechanisms and clinical potential remain under investigation, necessitating further studies to clarify its role in health and disease.
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