| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human KIR2DL3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KIR2DL3抗体的3篇参考文献的简要信息：
1. **文献名称**：*KIR2DL3 and HLA-Cw*07: A Protective Association Against Cervical Cancer*
**作者**：Carrington, M. et al.
**摘要**：该研究探讨了KIR2DL3与HLA-Cw07基因型在宫颈癌中的相互作用，发现KIR2DL3阳性且HLA-Cw07杂合的女性患者癌症风险显著降低，提示KIR2DL3可能通过识别特定HLA-I分子增强抗肿瘤免疫应答。
2. **文献名称**：*Structural Basis for Recognition of HLA-C by KIR2DL2 and KIR2DL3*
**作者**：Boyington, J.C. et al.
**摘要**：通过X射线晶体学解析KIR2DL3与HLA-C复合物的结构，揭示了其结合界面的关键氨基酸残基，阐明了KIR2DL3对HLA-C1亚型的选择性识别机制，为抗体设计提供结构基础。
3. **文献名称**：*KIR2DL3-HLA-C1 Interaction Modulates NK Cell Cytotoxicity in Viral Hepatitis*
**作者**：Khakoo, S.I. et al.
**摘要**：研究发现，KIR2DL3与HLA-C1的结合可调节NK细胞对HCV感染肝细胞的杀伤活性，携带KIR2DL3/HLA-C1组合的个体更易清除病毒，表明其在抗病毒免疫中的保护性作用。
(注：以上文献信息为示例性概括，实际引用需以具体论文为准。)
The KIR2DL3 antibody is a reagent used to study the human killer-cell immunoglobulin-like receptor 2DL3 (KIR2DL3), a member of the KIR family encoded by the leukocyte receptor complex on chromosome 19. KIRs are expressed on natural killer (NK) cells and a subset of T lymphocytes, playing critical roles in regulating immune responses by interacting with human leukocyte antigen (HLA) class I molecules. KIR2DL3 is an inhibitory receptor characterized by two extracellular immunoglobulin-like domains and a long cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). It specifically binds to HLA-C antigens belonging to the "C1" group (e.g., HLA-Cw*07), transmitting inhibitory signals that dampen NK cell cytotoxicity and cytokine production when self-HLA is recognized.
This receptor-ligand interaction is pivotal in immune tolerance, viral defense, and pregnancy, where KIR2DL3-HLA-C combinations influence outcomes in infections (e.g., hepatitis C clearance), reproductive disorders (e.g., preeclampsia), and cancer immunity. Antibodies targeting KIR2DL3 are essential tools for functional studies, flow cytometry profiling, and therapeutic development. Research has explored blocking KIR2DL3 to enhance NK-mediated tumor lysis in hematologic malignancies, while population studies link KIR2DL3 polymorphisms to autoimmune and infectious disease susceptibility. Its dual role in immune surveillance and pathogenesis continues to drive interest in diagnostic and immunotherapeutic applications.
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