| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CT111; URCC6; C10orf3 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CEP55 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEP55抗体的3篇参考文献摘要示例(注：文献标题及作者为虚构示例，仅供格式参考)：
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1. **文献名称**: "CEP55 overexpression promotes genomic instability and is associated with poor prognosis in breast cancer"
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫组化(IHC)和Western blot分析乳腺癌组织中CEP55蛋白表达水平，发现CEP55在肿瘤组织中显著上调，并与患者预后不良相关。实验表明CEP55过表达导致中心体异常和染色体分离错误，提示其作为乳腺癌潜在生物标志物的价值。
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2. **文献名称**: "CEP55 regulates cytokinesis through interaction with MKLP1 and Aurora B kinase"
**作者**: Smith JL, et al.
**摘要**: 利用CEP55特异性抗体进行免疫荧光和共聚焦显微镜观察，发现CEP55与MKLP1和Aurora B激酶在胞质分裂中相互作用。敲低CEP55导致胞质分裂失败，证实其在细胞分裂末期的关键调控作用。
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3. **文献名称**: "Targeting CEP55 as a therapeutic strategy in hepatocellular carcinoma"
**作者**: Wang X, et al.
**摘要**: 通过siRNA和CEP55抗体阻断实验，研究发现抑制CEP55表达可显著抑制肝癌细胞增殖并诱导凋亡。动物模型显示CEP55抗体靶向治疗可减少肿瘤生长，提示CEP55是肝癌治疗的潜在靶点。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词如 **"CEP55 antibody" + "cancer"/"cytokinesis"** 获取近期研究。
CEP55 (Centrosomal Protein 55) is a key regulator of cell division, primarily involved in cytokinesis and centrosome duplication. It localizes to the centrosome during interphase and relocates to the midbody during mitosis, facilitating the final separation of daughter cells. CEP55 interacts with proteins like ALIX and components of the ESCRT machinery to ensure proper abscission. Dysregulation of CEP55 is linked to genomic instability, mitotic errors, and cancer progression, with overexpression observed in various tumors, correlating with poor prognosis.
CEP55 antibodies are essential tools for studying its biological roles. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect CEP55 expression, subcellular localization, and interaction partners. These antibodies aid in exploring CEP55's oncogenic potential, including its role in promoting tumor proliferation, metastasis, and therapy resistance. Commercial CEP55 antibodies are typically raised against specific epitopes, with validation in knockout controls to ensure specificity. Research applications extend to investigating CEP55 as a potential cancer biomarker or therapeutic target, particularly in malignancies exhibiting chromosomal instability. Recent studies also examine its involvement in non-mitotic processes, such as membrane trafficking and cellular signaling pathways.
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