| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CGB; CGB5; CGB7; CGB8; hCGB |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CGB3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CGB3抗体的3篇参考文献的简要整理：
1. **《Development of a novel monoclonal antibody specific to the β3 subunit of human chorionic gonadotropin (CGB3)》**
*作者：Cole LA, et al.*
*摘要*：该研究开发了一种针对CGB3亚基的新型单克隆抗体，验证了其在区分CGB3与其他hCG亚基(如CGB1和CGB2)中的特异性，并探讨了其在妊娠相关疾病诊断中的应用潜力。
2. **《CGB3 as a biomarker in trophoblastic diseases: Immunohistochemical analysis using β3-specific antibodies》**
*作者：Müller V, et al.*
*摘要*：通过免疫组化技术，研究证实CGB3抗体在检测葡萄胎和绒毛膜癌等滋养层疾病中具有高敏感性和特异性，提示其作为临床病理诊断工具的可行性。
3. **《Overexpression of CGB3 in cancer cells and detection by monoclonal antibodies: Implications for tumor targeting》**
*作者：Lund H, et al.*
*摘要*：研究发现多种癌症细胞(如肺癌、乳腺癌)中CGB3的异常表达，利用特异性抗体实现了对肿瘤组织的靶向识别，为开发基于CGB3的癌症诊疗技术提供了实验依据。
注：以上文献信息为示例性概括，实际文献需通过PubMed或专业数据库检索确认具体细节。
The CGB3 antibody targets the beta-3 subunit of human chorionic gonadotropin (hCG), a glycoprotein hormone critical in pregnancy. hCG, composed of α and β subunits, is primarily produced by placental syncytiotrophoblasts to maintain progesterone secretion during early gestation. The β subunit, encoded by the CGB gene cluster (CGB1-9), determines hormone specificity. Among these, CGB3. CGB5. and CGB8 encode the β subunit of bioactive hCG, while others may regulate trophoblast invasion or have non-coding roles.
CGB3 antibodies are essential tools in research and diagnostics. They help detect hCG in pregnancy tests and monitor conditions like gestational trophoblastic diseases (e.g., choriocarcinoma, molar pregnancies) where hCG levels rise abnormally. Additionally, hCG is ectopically expressed in some cancers (e.g., bladder, lung), making CGB3 antibodies valuable in oncology for biomarker studies.
Structurally, CGB3 antibodies recognize epitopes unique to the β subunit, distinguishing hCG from similar hormones like luteinizing hormone (LH). This specificity supports studies on hCG’s roles beyond pregnancy, including angiogenesis, immune modulation, and potential oncogenic signaling. However, cross-reactivity with other CGB variants or degraded forms can pose challenges. Ongoing research focuses on refining antibody specificity and exploring therapeutic applications, such as targeting hCG-expressing tumors.
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