Rabbit Polyclonal COL20A1 Antibody

The COL20A1 antibody targets collagen type XX alpha 1 chain, a lesser-studied member of the collagen family encoded by the COL20A1 gene. Collagen XX, classified as a fibril-associated collagen with interrupted triple helices (FACIT), is implicated in tissue development and maintenance. Though its precise biological roles remain under investigation, COL20A1 is expressed in skeletal muscle, eyes, and developing tissues, suggesting potential involvement in myogenesis, ocular structure, or extracellular matrix organization. Antibodies against COL20A1 are primarily used in research to map its spatial distribution, quantify expression levels, and explore functional interactions in normal and pathological contexts. Due to limited commercial availability, many COL20A1 antibodies are custom-produced, requiring rigorous validation via knockout controls or siRNA-mediated gene silencing to confirm specificity. Emerging studies link COL20A1 dysregulation to connective tissue disorders and muscle-related pathologies, though mechanistic insights are sparse. Researchers employ these antibodies in techniques like immunohistochemistry, Western blotting, and immunofluorescence to address knowledge gaps in collagen XX's structural contributions and signaling roles. Challenges persist in distinguishing cross-reactivity with homologous collagens, necessitating careful experimental optimization.