首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal DHRS3 Antibody

  • 中文名: DHRS3抗体
  • 别    名: SDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1
货号: IPDX08239
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesSDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DHRS3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于DHRS3抗体的3篇模拟参考文献示例(注:以下内容为模拟生成,非真实文献,仅供参考):

---

1. **文献名称**: *DHRS3 modulates retinoic acid signaling through feedback regulation in stem cell differentiation*

**作者**: Smith, J., et al. (2015)

**摘要**: 本研究利用DHRS3特异性抗体通过Western blot和免疫荧光技术,揭示DHRS3通过负反馈调控视黄酸(RA)代谢通路,影响胚胎干细胞的定向分化。实验表明,DHRS3表达缺失会导致RA信号过度激活,从而扰乱细胞分化进程。

2. **文献名称**: *Downregulation of DHRS3 in hepatocellular carcinoma correlates with tumor progression and poor prognosis*

**作者**: Zhang, L., et al. (2018)

**摘要**: 通过免疫组化(使用DHRS3多克隆抗体)分析肝癌组织样本,发现DHRS3蛋白在肿瘤组织中显著低表达,且其表达水平与患者生存率呈正相关。机制研究表明,DHRS3可能通过抑制Wnt/β-catenin通路发挥抑癌作用。

3. **文献名称**: *Localization and functional analysis of DHRS3 during embryonic development using a novel monoclonal antibody*

**作者**: Johnson, R., et al. (2020)

**摘要**: 本研究开发了一种高特异性DHRS3单克隆抗体,并通过免疫组织化学技术在小鼠胚胎中定位DHRS3蛋白。结果显示,DHRS3在神经管和肢芽发育中高度表达,提示其在脊椎动物胚胎形态发生中的关键作用。

---

**备注**:以上文献信息为示例,实际研究中请通过PubMed、Web of Science等平台检索真实文献(关键词:DHRS3 antibody, retinoic acid, cancer, development)。若需具体文献协助,建议补充更详细的研究背景或应用场景。

背景信息

The DHRS3 antibody is a crucial tool in studying dehydrogenase/reductase 3 (DHRS3), a member of the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS3. also known as retinol dehydrogenase 11 (RDH11), plays a role in retinoid metabolism by catalyzing the oxidation of retinol to retinaldehyde, a key step in synthesizing retinoic acid—a critical signaling molecule in cell differentiation and development. This enzyme is implicated in lipid metabolism, cellular homeostasis, and cancer progression, with studies linking its expression to tumor suppression in cancers like colon and breast cancer. Researchers utilize DHRS3 antibodies primarily for detecting and quantifying DHRS3 protein levels in immunoassays such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically validated for specificity using knockout (KO) controls or siRNA-mediated knockdown to ensure minimal cross-reactivity with related SDR family members. Commercial DHRS3 antibodies are often produced in rabbits or mice, targeting specific epitopes within the protein's conserved regions. Recent studies have also explored DHRS3's role in metabolic disorders and its interaction with other retinoid-processing enzymes, underscoring the antibody's importance in both basic research and clinical applications. Proper validation and optimization of DHRS3 antibodies remain essential for reproducibility in studies investigating retinoid signaling pathways or DHRS3-associated diseases.

客户数据及评论

折叠内容

大包装询价

×