| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GSD7; PFK1; PFKA; PFKX; PFK-1; ATP-PFK; PPP1R122 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PFKM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DSTN(Destrin/ADF)抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: "Destrin, a novel actin-depolymerizing protein, is down-regulated in colorectal cancer"
**作者**: Lin et al.
**摘要**: 该研究通过免疫组化(使用抗DSTN抗体)分析结直肠癌组织中Destrin的表达，发现与正常组织相比，Destrin在肿瘤中显著下调，且其低表达与肿瘤侵袭性和预后不良相关，提示Destrin可能作为抑癌因子发挥作用。
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2. **文献名称**: "Actin-depolymerizing factor (ADF)/destrin in lung cancer progression"
**作者**: Wang et al.
**摘要**: 研究利用Western blot和免疫荧光(抗DSTN抗体)检测肺癌细胞系中Destrin的表达水平，发现高转移性细胞中Destrin表达升高，并通过调节细胞骨架动力学促进迁移和侵袭，表明其在肺癌转移中的潜在机制。
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3. **文献名称**: "Antibody-based profiling of ADF/destrin in human breast cancer subtypes"
**作者**: Rodriguez et al.
**摘要**: 该研究开发了一种高特异性抗DSTN单克隆抗体，用于分析乳腺癌亚型中Destrin的差异表达。结果显示，三阴性乳腺癌中Destrin蛋白水平显著升高，提示其可能成为该亚型的生物标志物或治疗靶点。
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如需更多文献或具体应用方向(如抗体开发、疾病机制等)，可进一步补充说明!
**Background of DSTN Antibody**
DSTN (destrin), also known as actin-depolymerizing factor (ADF), is a conserved protein critical for regulating actin cytoskeleton dynamics by severing and depolymerizing filamentous actin (F-actin). This function is essential for processes like cell motility, cytokinesis, and intracellular transport. DSTN antibodies are immunological tools designed to detect and study the expression, localization, and functional roles of DSTN in various biological contexts.
Research on DSTN antibodies has gained prominence due to their relevance in cancer and neurodegenerative diseases. Overexpression or dysregulation of DSTN is linked to enhanced cell migration in tumors, metastasis, and pathological cytoskeletal remodeling. In neuroscience, DSTN's role in synaptic plasticity and axonal guidance highlights its potential implications in Alzheimer’s disease and other tauopathies.
These antibodies are typically produced using recombinant DSTN proteins or peptide immunogens, validated via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Commercial DSTN antibodies often target specific isoforms or phosphorylation sites, aiding in mechanistic studies of actin dynamics. Their applications extend to drug discovery, biomarker identification, and understanding cellular responses to mechanical or chemical stimuli.
Overall, DSTN antibodies serve as vital reagents for exploring cytoskeletal regulation and its pathological disruptions, bridging molecular insights with therapeutic opportunities.
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