| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | REQ; UBID4; ubi-d4 |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DPF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与DPF2抗体相关的文献信息及摘要概括：
1. **文献名称**：DPF2 regulates the chromatin structure of neurodevelopmental genes in mouse embryonic stem cells
**作者**：Smith J, Doe R, et al.
**摘要**：本研究通过DPF2特异性抗体进行ChIP-seq分析，揭示DPF2作为BAF染色质重塑复合体组分，在小鼠胚胎干细胞神经分化过程中调控关键基因的染色质可及性，其缺失导致神经发育相关基因表达异常。
2. **文献名称**：DPF2 Antibody-Based Proteomic Profiling Identifies Its Overexpression in Aggressive Breast Cancer Subtypes
**作者**：Chen L, Wang X, et al.
**摘要**：利用DPF2单克隆抗体对乳腺癌组织进行免疫组化分析，发现DPF2在三阴性乳腺癌中显著高表达，且与患者预后不良相关，提示其可作为潜在治疗靶点。
3. **文献名称**：Structural Basis of DPF2 Recognition by a Therapeutic Antibody in B-cell Lymphoma
**作者**：Tanaka K, Yamamoto S, et al.
**摘要**：通过冷冻电镜解析DPF2与单克隆抗体的复合物结构，阐明抗体通过阻断DPF2与BAF复合体互作抑制淋巴瘤细胞增殖的分子机制，为抗体药物开发提供结构基础。
注：以上文献为示例性质，实际引用时请核对真实论文信息。建议通过PubMed或Web of Science以"DPF2 antibody"或"DPF2 BAF complex"为关键词检索最新研究。
**Background of DPF2 Antibody**
DPF2 (Double PHD Fingers 2), also termed SMARCG1 or BAF45d, is a component of the SWI/SNF chromatin remodeling complexes, particularly the BAF (BRG1/BRM-associated factor) subfamily. Characterized by two plant homeodomain (PHD) zinc fingers, DPF2 facilitates epigenetic regulation by binding histone modifications (e.g., H3K4me0) and recruiting chromatin remodelers to modulate gene expression. It plays critical roles in cellular differentiation, embryonic development, and neural function.
Dysregulation of DPF2 is implicated in diseases such as acute myeloid leukemia (AML), where mutations disrupt chromatin remodeling, and Coffin-Siris syndrome, a neurodevelopmental disorder linked to BAF complex deficiencies. DPF2 antibodies are essential tools for detecting its expression, localization, and protein interactions via techniques like immunoblotting, immunofluorescence, and ChIP-seq. These antibodies enable studies on DPF2’s mechanistic roles in chromatin dynamics, disease pathways, and potential therapeutic targeting, particularly in cancers and genetic disorders. Research using DPF2 antibodies continues to uncover its regulatory networks, emphasizing its significance in maintaining genomic stability and cellular identity.
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