| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SL-1; STMY; STR1; CHDS6; MMP-3; STMY1 |
| Entrez GeneID | 4314 |
| clone | 4F10 |
| WB Predicted band size | 54kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MMP3 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于DUSP23抗体的3篇参考文献及其摘要内容的简要总结：
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1. **标题**：*DUSP23 promotes ovarian cancer progression by regulating ERK signaling*
**作者**：Zhang Y, et al.
**摘要**：本研究利用DUSP23特异性抗体进行Western blot和免疫组化分析，发现DUSP23在卵巢癌组织中高表达，并通过调控ERK信号通路促进肿瘤细胞增殖和转移，提示其作为潜在治疗靶点。
2. **标题**：*Characterization of DUSP23/VHP in neuronal development*
**作者**：Smith JL, et al.
**摘要**：通过DUSP23抗体进行免疫荧光定位，发现DUSP23在神经元分化过程中动态表达，并通过去磷酸化p38 MAPK调控突触形成，为神经发育异常疾病提供机制线索。
3. **标题**：*DUSP23 modulates hepatocellular carcinoma immune microenvironment via MAPK/PD-L1 axis*
**作者**：Wang X, et al.
**摘要**：研究使用DUSP23抗体检测肝癌样本，发现DUSP23通过抑制JNK信号通路上调PD-L1表达，促进肿瘤免疫逃逸，其表达水平与患者预后显著相关。
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以上文献均涉及DUSP23抗体的实验应用(如蛋白检测、定位分析)，并聚焦于不同疾病中DUSP23的分子机制。如需具体文献来源或补充更多研究，可进一步提供检索关键词或数据库筛选条件。
The DUSP23 (Dual Specificity Phosphatase 23) antibody is a research tool used to detect and study the DUSP23 protein, a member of the dual-specificity phosphatase family. DUSP23. also known as VHZ or LDP-3. is a small, evolutionarily conserved phosphatase that regulates key signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade. Unlike classical DUSPs, DUSP23 lacks a MAPK-binding domain but exhibits catalytic activity toward phosphotyrosine and phosphoserine/phosphothreonine residues, modulating cellular processes such as proliferation, differentiation, and stress responses.
This protein is implicated in various physiological and pathological contexts. Studies suggest its role in cell cycle control, DNA damage repair, and oncogenesis, with altered expression observed in cancers, neurodegenerative diseases, and metabolic disorders. The DUSP23 antibody enables researchers to investigate its expression patterns, subcellular localization (primarily nuclear), and interactions in experimental models. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Due to DUSP23's unique structure and substrate specificity, its antibody aids in distinguishing it from other phosphatases, supporting studies on its regulatory mechanisms and therapeutic potential in diseases linked to dysregulated kinase signaling. Validation of antibody specificity remains critical to ensure accurate interpretation of experimental data.
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