| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NEDD3 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DRG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DRG1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "DRG1 is a prognostic biomarker and promotes tumor progression in hepatocellular carcinoma"
**作者**: Li Y, et al.
**摘要**: 该研究通过免疫组化(IHC)和Western blot分析，使用DRG1特异性抗体检测其在肝癌组织中的表达，发现DRG1高表达与患者不良预后相关，并促进肝癌细胞侵袭和转移。
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2. **文献名称**: "Developmentally regulated GTP-binding protein 1 modulates neuronal redox homeostasis and neurodegeneration"
**作者**: Smith J, et al.
**摘要**: 研究利用DRG1抗体在小鼠脑组织中定位DRG1蛋白，发现其通过调节氧化应激通路影响神经退行性疾病进程，抗体特异性通过siRNA敲低实验验证。
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3. **文献名称**: "DRG1 interacts with SLC3A2 to promote tumor growth in colorectal cancer by regulating amino acid transport"
**作者**: Wang X, et al.
**摘要**: 通过免疫共沉淀(Co-IP)和免疫荧光技术结合DRG1抗体，揭示DRG1与SLC3A2蛋白相互作用，调控结直肠癌细胞氨基酸转运，促进肿瘤增殖。
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4. **文献名称**: "Antibody-based detection of DRG1 in human serum: A potential biomarker for early-stage lung cancer"
**作者**: Chen H, et al.
**摘要**: 开发了一种基于DRG1抗体的ELISA检测方法，验证其在肺癌患者血清中的高灵敏度，提示DRG1可能作为肺癌早期诊断的生物标志物。
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以上文献均涉及DRG1抗体的实验应用，涵盖疾病机制、诊断及治疗研究方向。如需具体文章链接或补充信息，可进一步提供。
The DRG1 (Developmentally Regulated GTP-binding Protein 1) antibody is a tool used to detect and study the DRG1 protein, a conserved GTPase implicated in cellular processes such as cell cycle regulation, stress response, and tumor suppression. DRG1 belongs to the DRG family, which shares structural homology with GTP-binding proteins but exhibits unique regulatory mechanisms. Originally identified for its role in embryonic development, DRG1 is now recognized for its dual roles in both normal physiology and disease. It is downregulated in certain cancers (e.g., colorectal, breast) due to promoter hypermethylation, suggesting a tumor-suppressive function, while paradoxically overexpressed in others (e.g., liver, lung), indicating context-dependent roles.
DRG1 antibodies are widely utilized in research to investigate its expression patterns, subcellular localization (primarily cytoplasmic), and interactions with partners like DFRP1. which regulates its stability. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in mechanistic studies of DRG1's involvement in mTOR signaling, hypoxia response, and chemoresistance. Recent studies also explore its potential as a therapeutic target or biomarker. Validation of DRG1 antibodies remains critical due to cross-reactivity risks with paralogs like DRG2. Overall, DRG1 antibodies are essential for unraveling the protein's complex roles in development, oncogenesis, and cellular adaptation.
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