| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | XEDAR; EDAA2R; EDA-A2R; TNFRSF27 |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human EDA2R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EDA2R抗体的3篇参考文献摘要(文献信息为模拟示例)：
1. **文献名称**：Targeting EDA2R with a monoclonal antibody inhibits tumor angiogenesis in colorectal cancer
**作者**：Li X, et al.
**摘要**：本研究开发了一种靶向EDA2R的单克隆抗体(mAb-3C8)，通过阻断EDA2R与配体EDA-A2的结合，显著抑制结直肠癌模型中血管生成和肿瘤生长，提示其作为抗肿瘤治疗新策略的潜力。
2. **文献名称**：Structural basis of EDA2R recognition by a therapeutic antibody for alopecia treatment
**作者**：Zhang Y, et al.
**摘要**：通过冷冻电镜解析了抗EDA2R抗体(AD-203)与受体的复合物结构，揭示了抗体通过结合EDA2R胞外域CRD1区域阻断下游NF-κB信号通路的分子机制，为脱发症治疗提供理论依据。
3. **文献名称**：EDA2R-neutralizing antibody ameliorates autoimmune arthritis by suppressing osteoclastogenesis
**作者**：Tanaka K, et al.
**摘要**：研究发现抗EDA2R抗体(KTA-7)可抑制类风湿关节炎模型小鼠的破骨细胞分化和关节破坏，其作用与降低RANKL/EDA2R信号介导的MAPK磷酸化相关，提示该抗体在自身免疫疾病中的治疗价值。
注：以上文献为示例，实际引用时需核实真实发表的论文信息。
The EDA2R (Ectodysplasin A2 receptor) antibody is a research tool designed to target the EDAR protein, a member of the tumor necrosis factor receptor (TNFR) superfamily. EDAR plays a critical role in ectodermal development, particularly in the formation of skin appendages (hair, teeth, sweat glands) and immune system regulation. It binds to its ligand, EDA-A2. activating NF-κB signaling pathways that drive cell differentiation and tissue morphogenesis. Mutations in EDAR are strongly linked to X-linked hypohidrotic ectodermal dysplasia (XLHED), a disorder characterized by sparse hair, missing teeth, and impaired sweat gland development.
EDA2R antibodies are primarily used to study EDAR expression patterns in tissues, elucidate molecular mechanisms in developmental biology, and investigate disease models of ectodermal dysplasia. They enable detection of EDAR via techniques like Western blotting, immunohistochemistry, and flow cytometry. Recent studies also explore their potential in therapeutic strategies, such as agonist antibodies to reactivate EDAR signaling in XLHED patients. Commercial EDA2R antibodies are typically validated in human and murine samples, given the conserved role of EDAR across mammals. Researchers must consider cross-reactivity and isoform specificity when interpreting results, as EDAR variants may exhibit distinct functional roles.
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