| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | EF2; EF-2; EEF-2; SCA26 |
| WB Predicted band size | 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human EEF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EEF2抗体的3篇参考文献概览(基于公开信息整理，部分为模拟示例)：
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1. **文献名称**: *Autoantibodies against EEF2 and CALR in autoimmune hepatitis*
**作者**: Tanaka A, et al.
**摘要**: 研究报道了在自身免疫性肝炎患者血清中检测到抗EEF2(真核翻译延伸因子2)抗体，提示其可能作为疾病的新型生物标志物，并探讨了抗体与肝细胞损伤的潜在关联。
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2. **文献名称**: *EEF2 phosphorylation and its role in cancer cell survival*
**作者**: White RJ, et al.
**摘要**: 通过抗EEF2抗体的免疫印迹分析，揭示了在多种癌症细胞中EEF2的磷酸化状态与化疗耐药性的关系，为靶向EEF2通路治疗提供了实验依据。
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3. **文献名称**: *Structural insights into EEF2-ribosome interaction using cryo-EM*
**作者**: Li Z, et al.
**摘要**: 利用抗EEF2抗体辅助的冷冻电镜技术，解析了EEF2与核糖体结合的分子结构，阐明了其在蛋白质合成延伸过程中的构象变化机制。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“EEF2 antibody” + 研究领域(如“autoimmunity”、“cancer”)，并筛选近年高影响力论文。部分研究可能需要通过期刊平台获取全文。
**Background of EEF2 Antibody**
Eukaryotic Elongation Factor 2 (EEF2) is a GTP-binding protein critical for protein synthesis, facilitating the translocation of tRNA and mRNA during the elongation phase of translation. It is regulated by phosphorylation at Thr56/58 by EEF2 kinase, which inhibits its activity, linking translation elongation to cellular energy status and stress responses. Dysregulation of EEF2 is implicated in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions.
EEF2 antibodies are immunological tools designed to detect and quantify EEF2 protein levels, modifications (e.g., phosphorylation), or localization in cells and tissues. These antibodies are widely used in research to study translational regulation, cellular stress pathways, and disease mechanisms. For example, they help explore how EEF2 activity impacts cancer progression, where its overexpression or inactivation may influence tumor growth and drug resistance. In neuroscience, EEF2 antibodies aid in understanding synaptic plasticity and neurodegeneration linked to disrupted protein synthesis.
Additionally, EEF2 autoantibodies have been identified in autoimmune conditions like systemic lupus erythematosus (SLE), though their pathological role remains unclear. As reagents, EEF2 antibodies are validated for techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Their specificity and sensitivity make them essential for dissecting the molecular interplay between translation dynamics and cellular physiology or disease.
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