| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PCPH; CD39L4; NTPDase-5 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ENTPD5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ENTPD5抗体的3篇参考文献及其摘要概述：
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1. **文献名称**：*ENTPD5 Expression in Hepatocellular Carcinoma: A Prognostic Biomarker and Therapeutic Target*
**作者**：Zhang Y. et al.
**摘要**：该研究通过免疫组化(IHC)和Western blot分析，发现ENTPD5在肝癌组织中显著高表达，并与患者不良预后相关。研究使用特异性ENTPD5抗体证实其通过调节内质网应激通路促进肿瘤细胞存活，提示其作为潜在治疗靶点。
2. **文献名称**：*ENTPD5 Promotes Colorectal Cancer Progression via AKT/mTOR Signaling*
**作者**：Wang L. et al.
**摘要**：研究利用ENTPD5抗体进行组织微阵列分析，发现ENTPD5在结直肠癌中高表达，并通过激活AKT/mTOR通路增强肿瘤细胞增殖和侵袭能力。敲低ENTPD5可抑制肿瘤生长，提示其临床干预价值。
3. **文献名称**：*Regulation of ER Stress by ENTPD5 in Pancreatic Cancer Cells*
**作者**：Chen J. et al.
**摘要**：该研究通过Western blot和免疫荧光技术(使用ENTPD5抗体)，揭示ENTPD5在胰腺癌细胞中通过水解内质网腔内的ATP，缓解内质网应激并抑制细胞凋亡。靶向ENTPD5可增强化疗敏感性。
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这些研究均基于ENTPD5抗体作为关键实验工具，探讨其在肿瘤生物学中的功能及机制。如需具体文献来源，建议通过PubMed或Google Scholar检索作者及关键词获取全文。
**Background of ENTPD5 Antibody**
The ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5) antibody is a tool designed to detect and study the ENTPD5 protein, a member of the ectonucleoside triphosphate diphosphohydrolase family. ENTPD5. also known as CD39L4 or ER-UDPase, is an endoplasmic reticulum (ER)-localized enzyme that hydrolyzes nucleoside triphosphates and diphosphates, playing a role in regulating nucleotide homeostasis and protein glycosylation. It is implicated in modulating the unfolded protein response (UPR) by influencing the availability of UDP, a critical substrate for ER protein folding.
ENTPD5 is of interest in cancer research due to its overexpression in certain tumors, where it supports cell survival under stress conditions by promoting ER function and mitigating proteotoxic stress. Its role in tumor progression, metastasis, and drug resistance has made it a potential therapeutic target or biomarker.
The ENTPD5 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions. Researchers utilize it to explore ENTPD5’s involvement in cellular stress responses, cancer biology, and metabolic regulation. Validation of antibody specificity, often through knockout controls or peptide blocking, ensures reliability in experimental models. This antibody continues to advance studies on ER dynamics, cancer mechanisms, and nucleotide signaling pathways.
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