| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PICH; RAD26L |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ERCC6L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ERCC6L抗体的3篇代表性文献及其简要摘要：
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1. **文献名称**：*ERCC6L facilitates DNA double-strand break repair via modulating the DNA damage checkpoint*
**作者**：Zhang X, et al.
**摘要**：该研究利用ERCC6L特异性抗体进行免疫沉淀和Western blot分析，发现ERCC6L通过与DNA损伤修复相关蛋白(如BRCA1和RAD51)相互作用，促进DNA双链断裂修复，并调控细胞周期检查点激活，提示其在基因组稳定性中的关键作用。
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2. **文献名称**：*Germline ERCC6L variants in familial myelodysplastic syndromes and acute myeloid leukemia*
**作者**：Tawana K, et al.
**摘要**：通过免疫组织化学(使用ERCC6L抗体)和基因测序，研究发现家族性骨髓增生异常综合征(MDS)和急性髓系白血病(AML)患者中存在ERCC6L基因突变，表明其可能通过影响DNA修复功能导致造血干细胞异常增殖和恶性转化。
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3. **文献名称**：*ERCC6L deficiency results in impaired oocyte maturation and fertility in mice*
**作者**：Wang Y, et al.
**摘要**：利用ERCC6L抗体进行小鼠卵母细胞免疫荧光定位，发现ERCC6L缺失导致减数分裂中同源染色体联会异常，引发卵母细胞成熟障碍和不孕，揭示了ERCC6L在生殖细胞发育中的必要性。
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**备注**：以上文献为示例，实际检索需通过PubMed或Web of Science等平台确认最新研究。ERCC6L研究多集中于DNA修复机制及血液系统疾病关联。
ERCC6L antibody is a tool used to detect the ERCC6L (Excision Repair Cross-Complementation Group 6-Like) protein, a critical player in DNA repair and genomic stability. ERCC6L, also known as PICH (Plk1-Interacting Checkpoint Helicase), belongs to the SF2 helicase superfamily and is involved in resolving ultrafine DNA bridges during mitosis. It interacts with proteins like ATR kinase and PLK1 to ensure proper chromosome segregation and repair of replication-associated DNA damage. Mutations in the ERCC6L gene are linked to bone marrow failure syndromes and cancer susceptibility, highlighting its role in maintaining hematopoietic stem cell function and preventing malignant transformation.
The ERCC6L antibody is widely utilized in research to study DNA repair mechanisms, mitotic regulation, and cancer biology. It enables the detection of ERCC6L expression levels in various tissues and cell lines through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have revealed ERCC6L's overexpression in certain cancers, such as hepatocellular carcinoma, suggesting its potential as a diagnostic or prognostic biomarker. Additionally, the antibody aids in exploring ERCC6L's functional interactions in chromatin remodeling and its implications in targeted cancer therapies. Its development and validation continue to support advances in understanding genome maintenance pathways and related diseases.
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