| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | 2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FAM3B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAM3B抗体的示例参考文献(内容为假设性示例，建议通过学术数据库核实真实文献)：
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1. **文献名称**：*Development and characterization of a polyclonal antibody against human FAM3B for pancreatic islet studies*
**作者**：Xu, G., et al.
**摘要**：本研究开发并验证了一种兔源多克隆抗体，用于检测人FAM3B蛋白在胰岛β细胞中的表达。抗体通过ELISA和Western blot验证特异性，证实FAM3B在葡萄糖刺激下分泌增加，提示其参与胰岛素调节通路。
2. **文献名称**：*FAM3B/PANDER overexpression correlates with hepatocellular carcinoma progression and poor prognosis*
**作者**：Cao, Y., et al.
**摘要**：通过免疫组化分析肝癌组织样本，使用抗FAM3B抗体检测发现，FAM3B在肿瘤组织中高表达，且与血管侵袭和患者生存率下降显著相关，提示其作为肝癌潜在生物标志物的可能性。
3. **文献名称**：*FAM3B antibody-based inhibition ameliorates β-cell apoptosis in type 2 diabetic models*
**作者**：Yang, L., et al.
**摘要**：研究利用FAM3B中和抗体干预糖尿病小鼠模型，发现抗体处理显著减少β细胞凋亡并改善糖耐量，表明靶向FAM3B可能是糖尿病治疗的潜在策略。
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**注意**：以上文献信息为示例性质，实际引用请通过PubMed、Google Scholar等平台检索关键词“FAM3B antibody”“PANDER antibody”获取真实文献。
FAM3B (Family with sequence similarity 3 member B) is a gene encoding a cytokine-like protein named PANcreatic DERived factor (PANDER). Predominantly expressed in pancreatic β-cells, FAM3B/PANDER plays a role in glucose metabolism regulation and β-cell dysfunction. Structurally, it contains 224 amino acids with conserved cysteine residues forming disulfide bonds, resembling cytokine signaling motifs. Studies suggest FAM3B participates in apoptosis induction, insulin secretion modulation, and interactions with metabolic pathways like PI3K/AKT and AMPK. However, its precise mechanisms remain debated, with conflicting evidence on pro-apoptotic versus β-cell protective roles.
FAM3B antibodies are essential tools for detecting protein expression, localization, and functional studies. They are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate FAM3B's involvement in diabetes, pancreatic disorders, and cancers. Some studies link FAM3B overexpression to tumor progression in hepatocellular carcinoma and colorectal cancer. Commercial antibodies target specific epitopes (e.g., C-terminal regions) and are available as monoclonal or polyclonal variants. Validation in knockout models is critical due to potential cross-reactivity with FAM3 family paralogs. Research utilizing these antibodies continues to explore FAM3B's dual roles in metabolism and disease, highlighting its therapeutic and diagnostic potential.
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