| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FOP |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FGFR1OP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FGFR1OP抗体的参考文献示例(注：以下文献信息为模拟示例，实际文献需通过学术数据库验证)：
1. **文献名称**: "FGFR1OP as a novel biomarker in acute myeloid leukemia: Development and validation of a specific monoclonal antibody"
**作者**: Smith A, et al.
**摘要**: 研究报道了一种针对FGFR1OP蛋白的单克隆抗体的开发，验证了其在白血病细胞系中的特异性结合能力，并证明其可用于AML患者的骨髓样本中FGFR1OP异常表达的检测。
2. **文献名称**: "Functional characterization of FGFR1OP in tumorigenesis using a polyclonal antibody-based approach"
**作者**: Chen L, et al.
**摘要**: 通过多克隆抗体研究FGFR1OP在肿瘤发生中的作用，发现其在调控细胞周期和DNA修复中的功能，抗体成功用于Western blot和免疫组化分析。
3. **文献名称**: "FGFR1OP interaction networks revealed by co-immunoprecipitation with a high-affinity antibody"
**作者**: Johnson R, et al.
**摘要**: 利用高亲和力抗体进行免疫共沉淀实验，揭示了FGFR1OP与多种染色质修饰蛋白的相互作用，为白血病中染色体易位机制提供了新见解。
4. **文献名称**: "A comparative study of FGFR1OP antibody performance in diagnostic immunohistochemistry"
**作者**: Wang Y, et al.
**摘要**: 比较了不同商业化FGFR1OP抗体在福尔马林固定组织中的表现，筛选出适用于临床病理诊断的高特异性抗体。
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建议通过PubMed或Web of Science检索真实文献(关键词：FGFR1OP antibody, FGFR1OP monoclonal antibody)以获取准确信息。
The FGFR1OP (Fibroblast Growth Factor Receptor 1 Oncogenic Partner) antibody is a tool used to study the FGFR1OP protein, which is encoded by the *FGFR1OP* gene. This gene was initially identified as a partner in chromosomal translocations with the *FGFR1* gene in certain hematologic malignancies, particularly 8p11 myeloproliferative syndrome. The resulting fusion protein drives abnormal tyrosine kinase signaling, promoting oncogenesis. FGFR1OP itself is a conserved cytoplasmic protein implicated in cellular processes such as centrosome function, cytoskeletal organization, and cell cycle regulation, though its precise biological roles remain under investigation.
FGFR1OP antibodies are primarily utilized in research to detect and analyze the expression, localization, and interactions of FGFR1OP in normal and diseased tissues. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study FGFR1OP’s involvement in cancers, particularly those linked to FGFR1 rearrangements. Additionally, these antibodies help explore FGFR1OP’s potential role in non-cancer contexts, such as developmental biology or tissue repair. While not yet widely used in clinical diagnostics, FGFR1OP antibodies may hold future utility in identifying FGFR1-related malignancies or guiding targeted therapies. Their development and validation are critical for advancing understanding of FGFR1OP’s pathophysiological mechanisms and therapeutic relevance.
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