| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | FKBP38; FKBPr38 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FKBP8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FKBP8抗体的示例参考文献(内容为示例，非真实文献)：
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1. **文献名称**：*FKBP8 regulates mitochondrial apoptosis through interaction with Bcl-2 in colorectal cancer*
**作者**：Zhang L, et al.
**摘要**：本研究利用FKBP8特异性抗体检测其在结直肠癌组织中的表达，发现FKBP8通过抑制线粒体凋亡通路促进肿瘤存活，并与Bcl-2蛋白相互作用，提示其作为潜在治疗靶点。
2. **文献名称**：*FKBP8 modulates mitophagy by recruiting LC3 to damaged mitochondria*
**作者**：Tanaka K, et al.
**摘要**：通过免疫共沉淀(使用FKBP8抗体)和细胞成像技术，揭示了FKBP8在线粒体自噬中的关键作用，证明其通过LC3结合介导受损线粒体的清除，为神经退行性疾病机制提供新见解。
3. **文献名称**：*Tissue-specific expression profiling of FKBP8 in neurodegenerative disorders*
**作者**：Smith J, et al.
**摘要**：利用FKBP8抗体对帕金森病模型脑组织进行免疫组化分析，发现其表达异常与线粒体功能障碍相关，提示FKBP8在维持神经元存活中的调控作用。
4. **文献名称**：*Development of a novel FKBP8 monoclonal antibody for studying ER stress responses*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型FKBP8单克隆抗体的制备与验证，应用于内质网应激模型中，证明FKBP8通过mTOR通路调控细胞应激反应，为相关疾病研究提供工具。
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建议通过PubMed或Google Scholar检索真实文献(关键词：FKBP8 antibody, FKBP8 function, mitophagy, cancer)。
**Background of FKBP8 Antibody**
FKBP8 (FK506-binding protein 8), also known as FKBP38. is a member of the immunophilin protein family, characterized by its peptidyl-prolyl isomerase (PPIase) activity and interaction with immunosuppressive drugs like FK506. Unlike other FKBPs, FKBP8 lacks a canonical PPIase domain and is anchored to mitochondrial and endoplasmic reticulum membranes via a C-terminal transmembrane region. It plays critical roles in regulating apoptosis, autophagy, and mitochondrial function by interacting with Bcl-2 family proteins (e.g., Bcl-2 and Bcl-XL) and modulating mitochondrial outer membrane permeabilization.
FKBP8 antibodies are essential tools for studying its expression, localization, and functional mechanisms. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect FKBP8 in various tissues and cell lines. These antibodies often target specific epitopes, such as the N-terminal region or unique domains, to ensure specificity. Research links FKBP8 to cancer (e.g., influencing chemoresistance in glioblastoma) and neurodegenerative diseases (e.g., Parkinson’s via mitophagy regulation). However, its dual role as a pro- or anti-apoptotic factor, depending on cellular context, complicates interpretation. Challenges in detection arise from low endogenous expression or isoform-specific variants. Validated FKBP8 antibodies are crucial for elucidating its physiological and pathological roles, offering insights into therapeutic targeting of apoptosis-related disorders.
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