| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FUCA |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FUCA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FUCA1抗体的3篇参考文献，按文献名称、作者和摘要内容整理：
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1. **文献名称**：*"Development of a monoclonal antibody specific for human α-L-fucosidase (FUCA1) and its application in immunoblot analysis"*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对人源FUCA1酶的单克隆抗体，验证了其在Western blot和免疫组化中的应用。通过对比健康人与岩藻糖苷贮积症患者的组织样本，发现该抗体能特异性识别FUCA1蛋白的缺失，为疾病诊断提供了可靠工具。
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2. **文献名称**：*"Altered expression of FUCA1 in colorectal cancer: a novel biomarker for tumor progression"*
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化和Western blot分析，研究者发现FUCA1在结直肠癌组织中表达显著下调，且与患者预后不良相关。使用特异性FUCA1抗体证实了其作为肿瘤抑制因子的潜在作用，提示其在癌症治疗中的研究价值。
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3. **文献名称**：*"Functional characterization of FUCA1 mutations using a polyclonal antibody-based assay system"*
**作者**：Lee H, et al.
**摘要**：文章构建了针对FUCA1的多克隆抗体，用于检测不同基因突变导致的酶活性改变。通过患者细胞系分析，发现特定突变导致FUCA1蛋白稳定性下降，为岩藻糖苷贮积症的分子机制提供了新见解。
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**备注**：以上文献为示例，实际引用时请核对真实存在的论文及作者信息。若需具体文献，建议在PubMed或Web of Science中以“FUCA1 antibody”为关键词进一步检索。
FUCA1 antibody is a tool used to detect alpha-L-fucosidase 1 (FUCA1), a lysosomal enzyme encoded by the *FUCA1* gene in humans. This enzyme catalyzes the hydrolysis of fucose-containing glycosphingolipids and glycoproteins, playing a critical role in cellular glycoprotein turnover and lysosomal function. FUCA1 deficiency, caused by mutations in the *FUCA1* gene, leads to fucosidosis, a rare autosomal recessive lysosomal storage disorder characterized by progressive neurodegeneration, developmental delays, and tissue abnormalities.
FUCA1 antibodies are widely employed in research to study enzyme expression, localization, and regulatory mechanisms in both normal and pathological contexts. They are utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess FUCA1 protein levels in tissues or cell lines, aiding in the diagnosis or mechanistic investigation of fucosidosis. Additionally, these antibodies have gained attention in cancer research, as altered FUCA1 expression has been observed in certain tumors, suggesting potential roles in tumor progression or metastasis.
As a reagent, FUCA1 antibody serves as a critical tool for exploring lysosomal biology, genetic disorders, and disease biomarkers, bridging basic research with clinical applications in diagnostics and therapeutic development.
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