| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LCP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于LCP1抗体的参考文献摘要(基于公开文献信息整理，建议通过PubMed或期刊网站核实原文)：
---
1. **文献名称**：*L-plastin regulates the stability of the immune synapse of naive and effector T-cells*
**作者**：C. Leithner et al.
**摘要**：该研究利用LCP1抗体(抗L-plastin)探究T细胞免疫突触形成机制，发现LCP1通过稳定F-肌动蛋白网络调控T细胞受体信号传导，影响T细胞活化和功能。
---
2. **文献名称**：*Overexpression of LCP1 in oral squamous cell carcinoma and its association with lymph node metastasis*
**作者**：Y. Wang et al.
**摘要**：通过免疫组化(使用LCP1特异性抗体)分析口腔鳞癌组织中LCP1表达水平，发现其高表达与淋巴结转移及预后不良显著相关，提示LCP1可能作为肿瘤侵袭性标志物。
---
3. **文献名称**：*L-plastin phosphorylation regulates microglial motility and neuroinflammatory response*
**作者**：K. Smith et al.
**摘要**：研究采用LCP1抗体进行Western blot和免疫荧光，证明小胶质细胞中LCP1的磷酸化状态调控其迁移能力，进而影响神经炎症模型中炎症因子的释放。
---
4. **文献名称**：*Development and validation of a high-affinity monoclonal antibody against human LCP1 for flow cytometry applications*
**作者**：M. Tanaka et al.
**摘要**：报道一种新型抗人LCP1单克隆抗体的开发与验证，该抗体在流式细胞术中表现出高特异性和灵敏度，可用于免疫细胞亚群(如活化T细胞、巨噬细胞)的精准分型。
---
注：以上文献名为示例性描述，实际引用时需根据真实发表的文献调整标题及作者信息。建议通过关键词“LCP1 antibody”、“L-plastin immune response”或“LCP1 biomarker”在学术数据库中检索最新研究。
Lymphocyte Cytosolic Protein 1 (LCP1), also known as L-Plastin, is a member of the plastin family of actin-binding proteins. It plays a critical role in cytoskeletal reorganization, cell adhesion, and motility by crosslinking actin filaments. LCP1 is predominantly expressed in hematopoietic cells, including T cells, B cells, neutrophils, and macrophages, where it regulates immune cell functions such as migration, immune synapse formation, and phagocytosis. Its activity is modulated by calcium-dependent phosphorylation, particularly at serine residues, which influences interactions with cytoskeletal components.
LCP1 antibodies are essential tools for studying immune cell dynamics and related pathologies. In research, these antibodies are used to detect LCP1 expression in immune cells via techniques like Western blotting, immunofluorescence, and flow cytometry. Dysregulated LCP1 expression has been implicated in autoimmune diseases, chronic inflammation, and cancer metastasis. For example, elevated LCP1 levels in certain cancers correlate with enhanced tumor cell invasiveness, making it a potential biomarker for metastatic progression. Additionally, LCP1 antibodies aid in exploring its role in immune signaling pathways and evaluating therapeutic strategies targeting cytoskeletal remodeling. Their specificity and reliability make them valuable for both basic immunology studies and clinical investigations.
×
