Rabbit Polyclonal LZTFL1 Antibody

The Leucine Zipper Transcription Factor-like 1 (LZTFL1) protein is a poorly characterized member of the LZT protein family, implicated in ciliogenesis, intracellular trafficking, and cell signaling pathways. It contains a leucine zipper domain, suggesting potential roles in protein-protein interactions or transcriptional regulation. LZTFL1 antibodies are essential tools for studying its expression, localization, and function in cellular processes. Research has linked LZTFL1 to ciliary function, particularly through its interaction with the Bardet-Biedl syndrome (BBS) protein complex, which regulates primary cilia assembly and signaling. Dysregulation of LZTFL1 has been associated with ciliopathies, cancer progression, and respiratory diseases. Notably, a genetic variant near the LZTFL1 locus was identified as a risk factor for severe COVID-19. sparking interest in its role in pulmonary pathophysiology. Antibodies targeting LZTFL1 (often raised in rabbits or mice) enable detection via Western blotting, immunofluorescence, or immunohistochemistry, aiding investigations into its tissue-specific expression and subcellular distribution. Recent studies focus on its tumor-suppressive potential in certain cancers and its interplay with Hedgehog signaling, a cilia-dependent pathway. However, the exact molecular mechanisms remain unclear, underscoring the need for reliable antibodies to advance functional studies.