| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT1.8; MAGE8 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MAGEA8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAGEA8抗体的示例性参考文献(内容为模拟概括，建议通过学术数据库核实最新文献)：
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1. **标题**: *MAGEA8 as a novel biomarker in lung adenocarcinoma detected by monoclonal antibody*
**作者**: Zhang L, et al.
**摘要**: 研究开发了针对MAGEA8的单克隆抗体，证实其在肺腺癌组织中高表达，而在正常组织中几乎无表达。抗体通过免疫组化验证，可能作为肺癌诊断的潜在标志物。
2. **标题**: *Therapeutic potential of anti-MAGEA8 antibody in melanoma models*
**作者**: Smith J, et al.
**摘要**: 研究利用抗MAGEA8抗体在小鼠黑色素瘤模型中诱导抗体依赖性细胞毒性(ADCC)，显示肿瘤生长抑制，提示其作为免疫治疗靶点的可行性。
3. **标题**: *MAGEA8 antibody reveals differential expression in germ cell tumors*
**作者**: Tanaka K, et al.
**摘要**: 通过抗MAGEA8抗体分析生殖细胞肿瘤样本，发现其在精原细胞瘤中高表达，与临床分期相关，可能用于病理分型和预后评估。
4. **标题**: *Epitope mapping of MAGEA8-specific antibodies for T-cell activation*
**作者**: Müller R, et al.
**摘要**: 研究定位了MAGEA8抗体识别的抗原表位，并证明其可增强T细胞对肿瘤细胞的识别，为个性化疫苗设计提供理论基础。
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**注意**：以上文献信息为模拟生成，实际研究中请通过PubMed、Web of Science等平台以“MAGEA8 antibody”为关键词检索最新论文。真实研究多集中于MAGEA家族(如MAGEA3/4)，针对MAGEA8的抗体文献相对较少，建议扩展检索范围。
The melanoma-associated antigen A8 (MAGEA8) is a member of the MAGE family of cancer-testis antigens (CTAs), which are primarily expressed in germline cells and aberrantly reactivated in various cancers. Located on the X chromosome, MAGEA8 encodes a protein with a conserved MAGE homology domain, though its precise biological function remains unclear. Like other CTAs, MAGEA8 is normally silenced in somatic tissues due to promoter hypermethylation but becomes re-expressed in malignancies such as melanoma, lung cancer, and hepatocellular carcinoma, where it may contribute to tumorigenesis, immune evasion, or therapy resistance.
Antibodies targeting MAGEA8 are critical tools for studying its expression patterns, functional roles, and potential as a diagnostic or therapeutic biomarker. These antibodies enable detection via techniques like immunohistochemistry (IHC), Western blotting, or ELISA, aiding in correlating MAGEA8 levels with cancer progression or prognosis. Additionally, MAGEA8-specific antibodies are explored in immunotherapy contexts, such as chimeric antigen receptor (CAR) T-cell therapies or antibody-drug conjugates (ADCs), leveraging its tumor-restricted expression to minimize off-target effects.
However, challenges persist, including variable MAGEA8 expression across tumors, cross-reactivity with other MAGE proteins, and limited understanding of its interaction networks. Ongoing research aims to refine antibody specificity and evaluate clinical utility in personalized oncology approaches.
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