| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | OSR1 |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human OXSR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是假设性的关于OXSR1抗体的参考文献示例(实际文献需通过学术数据库验证)：
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1. **文献名称**：*OXSR1 promotes tumor progression through AMPK signaling in triple-negative breast cancer*
**作者**：Zhang Y, et al.
**摘要**：本研究利用OXSR1抗体通过免疫组化分析发现，OXSR1在三阴性乳腺癌组织中高表达，且与患者预后不良相关。实验表明OXSR1通过激活AMPK通路促进肿瘤细胞增殖和转移。
2. **文献名称**：*OXSR1-mediated drug resistance in colorectal cancer via regulation of ABC transporters*
**作者**：Meng L, et al.
**摘要**：研究通过Western blot和免疫荧光(使用OXSR1抗体)证实，OXSR1过表达通过上调ABC转运蛋白家族成员，导致结直肠癌细胞对化疗药物产生耐药性。
3. **文献名称**：*OXSR1 modulates tau phosphorylation in Alzheimer’s disease models*
**作者**：Deng X, et al.
**摘要**：该文献利用OXSR1抗体检测阿尔茨海默病小鼠脑组织，发现OXSR1与tau蛋白异常磷酸化相关，提示其在神经退行性病变中的氧化应激调控作用。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Web of Science等平台检索。如需具体文献，建议使用关键词“OXSR1 antibody”或“OXSR1 kinase”查询最新研究。
The OXSR1 (Oxidative Stress Responsive 1) antibody is a tool used to detect the OXSR1 protein, a serine/threonine kinase involved in cellular stress responses and ion transport regulation. OXSR1. also known as OSR1. is part of the STE20 kinase family and interacts with SPAK (STE20/SPS1-related proline-alanine-rich kinase) to modulate ion co-transporters like NKCC1/2. which are critical for maintaining electrolyte balance. This kinase is activated under oxidative stress or osmotic changes, often through phosphorylation by upstream WNK (With-No-Lysine) kinases, linking it to pathways that control blood pressure, neuronal function, and kidney homeostasis.
OXSR1 antibodies are widely used in research to study its expression, localization, and activation status in tissues or cell lines. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, helping to elucidate OXSR1's role in diseases such as hypertension, neuropathologies, and renal disorders. Dysregulation of OXSR1/SPAK signaling is associated with abnormal ion transport in hypertension models, while its stress-responsive nature implicates it in neurodegenerative conditions. These antibodies often target specific phosphorylated residues (e.g., Thr185/Ser325) to assess activation dynamics. Researchers also use them to explore therapeutic strategies targeting the WNK-SPAK/OSR1 axis, aiming to correct ion transport defects. Validation in knockout models ensures specificity, making OXSR1 antibodies vital for mechanistic studies in physiology and disease.
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