| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT16.4; GAGEC2; GAGEE2; PAGE-2 |
| WB Predicted band size | 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PAGE2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PAGE2抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**: *PAGE2 is a member of the cancer/testis antigen family associated with prostate cancer progression*
**作者**: Brinkmann U, et al.
**摘要**: 该研究鉴定了PAGE2作为癌症/睾丸抗原(CT抗原)家族成员，在前列腺癌中异常表达。研究利用特异性抗体证实PAGE2蛋白在肿瘤组织中的表达升高，并与疾病侵袭性相关，提示其作为潜在生物标志物的价值。
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2. **文献名称**: *Immunohistochemical analysis of PAGE2 expression in human tissues using a novel monoclonal antibody*
**作者**: Smith LM, et al.
**摘要**: 作者开发了一种针对PAGE2的新型单克隆抗体，并通过免疫组化验证其在正常前列腺、睾丸及多种癌症组织中的表达模式。结果显示PAGE2在癌细胞中的特异性表达，支持其在癌症免疫治疗中的研究潜力。
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3. **文献名称**: *Cancer/testis antigen PAGE2 promotes cell proliferation via MAPK signaling in prostate cancer*
**作者**: Wang Y, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术(使用PAGE2特异性抗体)发现，PAGE2通过激活MAPK通路促进前列腺癌细胞增殖，为靶向PAGE2的抗体药物开发提供了理论依据。
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**备注**：以上文献信息为模拟示例，实际文献需通过PubMed或Google Scholar等平台检索确认。若需具体文献链接或补充，可提供进一步信息。
The PAGE2 (P antigen family member 2) antibody is a tool used to study the PAGE2 protein, a member of the cancer/testis antigen (CTA) family. CTAs are proteins typically expressed in germ cells (e.g., testes) but silenced in most somatic tissues. Their aberrant re-expression in various cancers, including prostate cancer, melanoma, and breast cancer, has linked them to tumorigenesis and immune evasion. PAGE2. encoded by the *PAGE2* gene on the X chromosome, shares structural homology with other GAGE/PAGE family members, characterized by conserved glycine-rich regions and putative roles in protein-protein interactions.
Research using PAGE2 antibodies focuses on elucidating its biological function, which remains poorly understood. Studies suggest PAGE2 may regulate transcription, cell proliferation, or apoptosis, potentially influencing cancer progression. Its restricted expression in healthy tissues and reactivation in tumors make it a candidate biomarker for cancer diagnosis or immunotherapy targets. PAGE2 antibodies are employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression patterns in clinical samples or cell lines.
Despite its potential, PAGE2's exact mechanisms and clinical relevance require further exploration. Antibody specificity remains critical due to high sequence similarity among PAGE/GAGE family members. Current efforts aim to validate PAGE2's role in oncogenesis and its utility in liquid biopsies or therapeutic strategies, emphasizing its dual significance in basic and translational cancer research.
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