| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | LMP1; LMP3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PDLIM7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PDLIM7抗体的3篇参考文献示例(注：文献为虚构示例，实际文献需通过学术数据库检索)：
1. **"PDLIM7 regulates cell adhesion and cancer metastasis via actin cytoskeleton remodeling"**
- **作者**: Nagase T, et al.
- **摘要**: 研究利用PDLIM7抗体揭示了其在调节细胞黏附和转移中的作用，发现PDLIM7通过稳定丝状肌动蛋白抑制乳腺癌细胞迁移。
2. **"Expression profiling of PDLIM7 in prostate cancer and its correlation with patient prognosis"**
- **作者**: Cheng L, et al.
- **摘要**: 通过免疫组化(使用PDLIM7抗体)分析前列腺癌组织，发现PDLIM7低表达与肿瘤侵袭性及不良预后显著相关。
3. **"PDLIM7 interacts with Smad proteins to modulate TGF-β signaling in fibrosis"**
- **作者**: Zhang Y, et al.
- **摘要**: 研究采用PDLIM7抗体进行共免疫沉淀实验，证实PDLIM7与Smad3结合，负调控TGF-β信号通路，影响纤维化进程。
如需真实文献，建议在PubMed或Google Scholar检索关键词“PDLIM7 antibody”或“PDLIM7 function”。
The PDLIM7 antibody is a research tool designed to detect and study the protein PDZ and LIM domain protein 7 (PDLIM7), also known as enigma or LIM mineralization protein. PDLIM7 belongs to the LIM domain protein family, characterized by tandem cysteine-rich zinc-binding motifs (LIM domains) and a PDZ domain, which mediate protein-protein interactions and subcellular localization. This protein plays roles in cytoskeletal organization, signal transduction, and transcriptional regulation, particularly in pathways involving cell adhesion, differentiation, and stress responses.
PDLIM7 is implicated in diverse physiological and pathological processes, including bone formation, cardiac development, and cancer. Studies suggest it acts as a scaffold protein, linking signaling molecules like protein kinases or transcription factors (e.g., NF-κB) to specific cellular compartments. In cancer, PDLIM7 may promote tumor progression by enhancing cell migration, invasion, and metastasis, though its precise mechanisms remain under investigation. Dysregulation of PDLIM7 has been observed in malignancies such as breast, prostate, and liver cancers.
The PDLIM7 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions. Its specificity and sensitivity are critical for elucidating PDLIM7's functional roles in normal and diseased states. Researchers utilize this antibody to explore its potential as a biomarker or therapeutic target, particularly in oncology. Validation of antibody performance, including cross-reactivity and epitope mapping, is essential for reliable experimental outcomes.
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