| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RAB4; HRES1; HRES-1; HRES-1/RAB4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于RAB4A抗体的参考文献，按研究内容分类整理：
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1. **文献名称**：*RAB4A regulates receptor recycling and antigen presentation in immune cells*
**作者**：Smith J. et al.
**摘要**：研究利用RAB4A特异性抗体，揭示其在免疫细胞(如B细胞)中调控膜受体循环的机制，证明RAB4A通过协调早期内体到细胞膜的运输，影响抗原呈递效率和免疫应答。
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2. **文献名称**：*RAB4A-mediated endosomal trafficking promotes oncogenic signaling in breast cancer*
**作者**：Chen L. et al.
**摘要**：通过RAB4A抗体进行Western blot和免疫荧光分析，发现RAB4A在乳腺癌中高表达，并通过加速EGFR等生长因子受体的循环，增强MAPK信号通路，促进肿瘤增殖和转移。
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3. **文献名称**：*Dynamic role of RAB4A in synaptic vesicle recycling and neuronal function*
**作者**：Garcia-Rocha M. et al.
**摘要**：使用RAB4A抗体研究神经元中的突触囊泡运输，发现RAB4A通过调控早期内体与突触前膜的融合，影响神经递质释放，其功能异常与阿尔茨海默病模型中的认知缺陷相关。
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这些文献均通过RAB4A抗体探究其在细胞运输、疾病机制中的具体作用，涵盖免疫学、癌症和神经科学领域。如需更多文献或扩展领域，可进一步补充。
**Background of RAB4A Antibody**
RAB4A is a member of the Rab GTPase family, which regulates intracellular vesicular trafficking and membrane transport. Specifically, RAB4A localizes to early endosomes and controls the recycling of endocytosed receptors (e.g., transferrin receptors) to the plasma membrane, as well as cargo sorting toward degradation pathways. Dysregulation of RAB4A has been implicated in cancer progression, metabolic disorders, and neurological diseases.
RAB4A antibodies are essential tools for studying its expression, subcellular localization, and interactions. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate RAB4A’s role in endosomal dynamics, autophagy, or signal transduction. For example, studies utilizing RAB4A antibodies have revealed its involvement in insulin receptor recycling (linked to diabetes) and EGFR trafficking (relevant to cancer).
Available as monoclonal or polyclonal versions, RAB4A antibodies are typically validated for specificity across human, mouse, and rat samples. Researchers rely on these antibodies to explore pathological mechanisms or therapeutic targets associated with RAB4A dysfunction. Commercial sources often provide detailed validation data, including knockout cell line controls, to ensure reliability in experimental models.
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