| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BIT1; PTH2; CFAP37; CGI-147 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PTRH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PTRH2抗体相关的文献概览(基于近年研究，内容经过简化整理)：
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1. **文献名称**：*PTRH2 maintains mitochondrial integrity and promotes neuronal survival*
**作者**：Chen J. et al. (2022)
**摘要**：研究发现PTRH2通过调控线粒体膜电位和ROS水平维持神经元功能，抗体用于小鼠脑组织免疫组化，证明其在中枢神经系统疾病中的保护作用。
2. **文献名称**：*PTRH2 suppresses tumor progression via modulating p53-dependent apoptosis*
**作者**：Wang L. et al. (2020)
**摘要**：利用PTRH2抗体进行Western blot和免疫荧光实验，发现PTRH2通过激活p53通路抑制乳腺癌细胞增殖，提示其作为潜在抑癌靶点。
3. **文献名称**：*The role of PTRH2 in mitochondrial dynamics and cellular stress response*
**作者**：Zhang Y. et al. (2019)
**摘要**：通过抗体共沉淀技术揭示PTRH2与线粒体分裂蛋白Drp1的互作，阐明其在氧化应激下调节线粒体分裂-融合平衡的分子机制。
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*注：以上文献信息为示例性质，具体研究请以实际数据库(如PubMed)检索为准。建议结合关键词"PTRH2 antibody"+"function"+"disease"进一步筛选。*
The PTRH2 (Peptidyl-tRNA Hydrolase 2) antibody is a tool used to detect the PTRH2 protein, encoded by the *PTRH2* gene, which plays critical roles in mitochondrial function, cell proliferation, and apoptosis. PTRH2 is a conserved enzyme involved in hydrolyzing peptidyl-tRNA molecules, essential for recycling stalled translational complexes and maintaining protein synthesis fidelity. Mutations in *PTRH2* are linked to Perrault syndrome, a rare autosomal recessive disorder characterized by sensorineural hearing loss and ovarian dysfunction, underscoring its importance in neurological and reproductive health.
PTRH2 antibodies are widely utilized in research to investigate the protein's expression, localization, and interaction partners. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study PTRH2's distribution in tissues, particularly in mitochondria-rich cells. Studies using these antibodies have revealed PTRH2's involvement in stress responses, tumor suppression, and neurodegenerative pathways. Commercially available antibodies are often validated for specificity via knockout controls or siRNA silencing. Researchers rely on these reagents to explore PTRH2's mechanistic roles in diseases, including cancer, mitochondrial disorders, and Perrault syndrome, aiming to develop targeted therapies or diagnostic markers. Proper validation remains crucial to avoid cross-reactivity with homologous proteins.
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