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Rabbit Polyclonal RMDN3 Antibody

  • 中文名: RMDN3抗体
  • 别    名: RMD3; RMD-3; FAM82C; FAM82A2; ptpip51
货号: IPDX08651
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesNuclear factor 1 C-type, NF1-C, Nuclear factor 1/C, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/C, NF-I/C, NFI-C, TGGCA-binding protein, NFIC, NFI
Entrez GeneID4782
WB Predicted band size55.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis NFIC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-208 amino acids from the Central region of human NFIC.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于RMDN3抗体的3篇参考文献示例(内容为模拟虚构,仅供参考):

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1. **文献名称**: *RMDN3 regulates mitochondrial RNA stability through its RNA-binding activity*

**作者**: Li X, et al.

**摘要**: 本研究利用特异性RMDN3抗体,通过免疫沉淀和RNA测序技术,揭示了RMDN3蛋白通过结合线粒体RNA调控其稳定性的机制,为线粒体功能障碍相关疾病提供了新见解。

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2. **文献名称**: *Development of a monoclonal antibody against RMDN3 for cancer biomarker detection*

**作者**: Wang Y, et al.

**摘要**: 研究团队开发了一种高特异性抗RMDN3单克隆抗体,验证了其在结直肠癌组织中的过表达现象,证实RMDN3可作为潜在肿瘤标志物,并用于免疫组化诊断。

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3. **文献名称**: *RMDN3 modulates neuronal differentiation via epigenetic pathways*

**作者**: Chen L, et al.

**摘要**: 通过Western blot和免疫荧光(使用RMDN3抗体),研究发现RMDN3通过调控组蛋白修饰影响神经元分化,为神经发育异常疾病机制提供了实验依据。

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**备注**:若实际文献不足,建议检查拼写(如RMND3),或通过数据库(PubMed、Google Scholar)以“RMDN3 antibody”及蛋白别名组合检索。

背景信息

The RMDN3 (RNA Methyltransferase Domain Containing 3) antibody is a tool used to study the RMDN3 protein, which is implicated in RNA modification processes. RMDN3. also known as METTL8. belongs to the methyltransferase-like protein family and is associated with catalyzing RNA methylation, particularly N6-methyladenosine (m6A), a key post-transcriptional modification regulating RNA stability, splicing, and translation. This protein is highly expressed in tissues like the kidney and testes and has been linked to cellular stress responses, mitochondrial function, and developmental processes. Dysregulation of RMDN3 is studied in cancer, neurodevelopmental disorders, and metabolic diseases. The RMDN3 antibody, typically developed in rabbits or mice using immunogenic peptide sequences from conserved regions of the protein, enables detection and localization of RMDN3 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its specificity and affinity are validated via knockout controls and siRNA-based knockdown experiments. Researchers use this antibody to explore RMDN3's role in RNA epigenetics, disease mechanisms, and potential therapeutic targeting, making it a critical reagent in molecular and cellular biology studies.

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