| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PDH; PDP; PDPC; PPM2A; PPM2C |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PDP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于PDP1抗体的示例参考文献(注：以下内容为模拟示例，建议通过学术数据库检索真实文献)：
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1. **文献名称**：*"Development and Validation of a Specific Polyclonal Antibody for Human PDP1 in Mitochondrial Studies"*
**作者**：Chen et al.
**摘要**：本研究开发了一种针对人源PDP1的高特异性兔多克隆抗体，并通过Western blot和免疫荧光验证其在细胞线粒体定位中的应用。抗体成功用于检测PDP1在代谢疾病模型中的表达下调。
2. **文献名称**：*"PDP1 Antibody-Based Profiling Reveals Tissue-Specific Expression in Murine Models"*
**作者**：Rodriguez et al.
**摘要**：利用新开发的PDP1单克隆抗体，分析了小鼠心脏、肝脏和肌肉组织中PDP1的表达差异，发现其在能量需求高的组织中表达显著，为研究代谢调控机制提供工具。
3. **文献名称**：*"Targeting PDP1 in Cancer Metabolism: An Antibody-Mediated Functional Study"*
**作者**：Kimura et al.
**摘要**：通过抑制性抗体阻断PDP1活性，研究其对癌细胞糖酵解和三羧酸循环的影响，揭示了PDP1作为潜在癌症治疗靶点的作用。
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**建议**：如需真实文献，可在PubMed或Google Scholar中检索关键词“PDP1 antibody”、“PDP1 immunoblotting”或结合具体研究领域(如“mitochondrial metabolism”)。
The PDP1 (Pyruvate Dehydrogenase Phosphatase 1) antibody is a tool used to study the regulatory enzyme PDP1. which plays a critical role in glucose metabolism. PDP1 is a mitochondrial phosphatase that activates the pyruvate dehydrogenase complex (PDC) by dephosphorylating its E1 subunit, enabling PDC to convert pyruvate to acetyl-CoA. This step links glycolysis to the tricarboxylic acid (TCA) cycle, making PDP1 essential for cellular energy production. Dysregulation of PDP1 is implicated in metabolic disorders, including diabetes, obesity, and mitochondrial diseases.
Antibodies targeting PDP1 are utilized in research to detect its expression levels, localization, and interactions in tissues or cell lines. They help elucidate PDP1's role in metabolic pathways, insulin signaling, and its potential as a therapeutic target. For example, reduced PDP1 activity is associated with impaired glucose oxidation in diabetes, while overexpression may influence lipid metabolism. Western blotting, immunohistochemistry, and immunofluorescence are common applications.
Recent studies also explore PDP1's involvement in cancer, as altered PDC activity affects cancer cell proliferation. The PDP1 antibody thus serves as a vital reagent for understanding metabolic regulation and disease mechanisms, bridging molecular biology with clinical research.
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