| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | P2; MP2; FABP8; M-FABP |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PMP2抗体的3篇文献示例(注：文献为虚拟示例，实际检索需通过学术数据库验证)：
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1. **文献名称**：*PMP2 Antibody Characterization in Demyelinating Neuropathies*
**作者**：Smith A, et al.
**摘要**：本研究开发并验证了一种高特异性PMP2单克隆抗体，通过免疫组化和Western blot分析，证实其在周围神经活检样本中检测髓鞘蛋白表达的可靠性，为周围神经病变的病理诊断提供工具。
2. **文献名称**：*Role of PMP2 in Lipid Metabolism of Schwann Cells: Insights from Knockout Mice*
**作者**：Zhang L, et al.
**摘要**：利用PMP2抗体探究PMP2基因敲除小鼠的施万细胞脂质代谢异常，发现PMP2缺失导致髓鞘结构紊乱，提示其在维持髓鞘脂质稳态中的关键作用。
3. **文献名称**：*Autoantibodies Against PMP2 in Chronic Inflammatory Demyelinating Polyneuropathy*
**作者**：Tanaka K, et al.
**摘要**：通过ELISA和免疫荧光技术，首次报道慢性炎性脱髓鞘性神经病(CIDP)患者血清中存在抗PMP2自身抗体，提示其潜在致病机制及作为生物标志物的可能性。
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如需实际文献，建议在PubMed或Google Scholar中以“PMP2 antibody”或“FABP8 antibody”为关键词检索，并筛选涉及抗体开发、验证或疾病机制的研究。
**Background of PMP2 Antibody**
The Peripheral Myelin Protein 2 (PMP2), also known as Fatty Acid Binding Protein 8 (FABP8), is a small lipid-binding protein critical for the formation and maintenance of myelin sheaths in the peripheral nervous system. It facilitates the transport of fatty acids and other lipids to Schwann cells, supporting membrane synthesis and stability during myelination. PMP2 mutations are linked to Charcot-Marie-Tooth disease (CMT), a hereditary neuropathy characterized by muscle weakness and sensory loss.
PMP2 antibodies are essential tools for studying the protein’s expression, localization, and function in both healthy and diseased states. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to analyze PMP2 distribution in neural tissues, assess its role in lipid metabolism, and investigate its association with demyelinating disorders. Recent research also explores PMP2’s potential as a biomarker for neuropathies and its interactions with other myelin components.
These antibodies contribute to advancing understanding of peripheral nerve biology and developing therapeutic strategies for CMT and related conditions. Commercial PMP2 antibodies are typically validated for specificity in human, mouse, and rat models, supporting translational research in neurology and genetics.
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