| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | BMND18; T-plastin |
| WB Predicted band size | 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PLS3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLS3抗体的模拟参考文献示例(请注意，这些为示例性质，实际文献需通过学术数据库获取)：
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1. **"PLS3 Antibody Validation in Osteogenesis Imperfecta Models"**
*Author: Smith J, et al.*
*摘要*：本研究验证了PLS3抗体在成骨不全症小鼠模型中的应用，通过Western blot和免疫荧光确认抗体特异性，发现PLS3表达缺失与骨密度降低相关。
2. **"T-Plastin (PLS3) as a Biomarker in Metastatic Breast Cancer"**
*Author: Chen L, et al.*
*摘要*：文章利用PLS3抗体进行免疫组化分析，发现PLS3在转移性乳腺癌组织中高表达，提示其可能作为癌症侵袭性的潜在标志物。
3. **"Development of a Monoclonal Antibody Against Human PLS3 for Diagnostic Use"**
*Author: Müller R, et al.*
*摘要*：报道了一种针对人源PLS3蛋白的单克隆抗体的开发，通过ELISA和流式细胞术验证其灵敏度，并探讨其在遗传性骨骼疾病诊断中的应用。
4. **"PLS3-Mediated Actin Cytoskeleton Remodeling in Neuronal Development"**
*Author: Tanaka K, et al.*
*摘要*：研究使用PLS3抗体探究T-Plastin在神经元突触形成中的作用，发现其通过调节肌动蛋白重组影响突触可塑性。
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建议通过PubMed、Google Scholar等平台以关键词“PLS3 antibody”或“T-Plastin antibody”检索最新文献，获取具体研究细节。
PLS3 (plastin 3) is a calcium-binding actin-bundling protein encoded by the *PLS3* gene, primarily involved in regulating cytoskeletal dynamics. It stabilizes actin filaments, facilitating cellular processes like motility, adhesion, and intracellular transport. PLS3 gained attention due to its role as a genetic modifier in spinal muscular atrophy (SMA), where its overexpression can ameliorate symptoms in some patients, suggesting therapeutic potential. Additionally, PLS3 is implicated in cancer progression, particularly in metastasis, by enhancing invasive properties of tumor cells through actin remodeling.
PLS3 antibodies are tools used to detect and study the expression, localization, and function of the PLS3 protein in research and diagnostics. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to analyze PLS3 levels in tissues or cell lines. In cancer research, PLS3 antibodies help investigate its association with metastatic behavior, while in neuromuscular studies, they aid in understanding its protective role in SMA. Commercially available PLS3 antibodies vary in specificity (monoclonal vs. polyclonal) and are validated for applications across species, including humans and mice. However, cross-reactivity and validation in specific experimental models remain critical considerations. Overall, PLS3 antibodies are vital for elucidating the protein's biological roles and its potential as a biomarker or therapeutic target.
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