| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PTPH1; PTP-H1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PTPN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTPN3抗体的3篇示例文献(内容为模拟概括，仅供参考)：
1. **文献名称**：*PTPN3 suppresses hepatocellular carcinoma through dephosphorylation of STAT3*
**作者**：Zhang Y. et al.
**摘要**：研究发现PTPN3通过去磷酸化STAT3抑制肝癌细胞增殖，抗体的免疫组化分析显示PTPN3在肝癌组织中低表达，与患者不良预后相关。
2. **文献名称**：*PTPN3 regulates HER2 signaling and resistance to targeted therapy in breast cancer*
**作者**：Li H. et al.
**摘要**：利用PTPN3特异性抗体验证其在乳腺癌组织中的表达，发现PTPN3通过调控HER2信号通路影响曲妥珠单抗耐药性，沉默PTPN3可增强药物敏感性。
3. **文献名称**：*PTPN3 interacts with hepatitis B virus core protein and promotes viral replication*
**作者**：Wang X. et al.
**摘要**：通过免疫共沉淀(使用PTPN3抗体)发现PTPN3与HBV核心蛋白结合，促进病毒复制，提示其可作为抗病毒治疗潜在靶点。
4. **文献名称**：*Antibody-based detection of PTPN3 in gastric cancer: A prognostic biomarker study*
**作者**：Chen L. et al.
**摘要**：基于抗体的组织染色技术分析PTPN3在胃癌中的表达，证实其高表达与患者生存期延长相关，机制涉及抑制MAPK通路活化。
建议通过PubMed或Google Scholar检索真实文献，输入关键词“PTPN3 antibody”或“PTPN3 phosphatase”获取最新研究。
**Background of PTPN3 Antibody**
PTPN3 (Protein Tyrosine Phosphatase Non-Receptor Type 3), also known as PTPH1. is a member of the protein tyrosine phosphatase (PTP) family, which regulates critical cellular processes by dephosphorylating tyrosine residues on target proteins. PTPN3 is characterized by an N-terminal FERM (4.1. ezrin, radixin, moesin) domain, which facilitates membrane localization and protein-protein interactions, and a C-terminal catalytic phosphatase domain. It is implicated in diverse signaling pathways, including MAPK, EGFR, and JNK cascades, influencing cell proliferation, differentiation, and apoptosis.
Dysregulation of PTPN3 has been linked to multiple diseases, particularly cancers. Studies suggest its role as both a tumor suppressor and oncogene, depending on cellular context. For example, PTPN3 loss or mutations are associated with hepatocellular carcinoma and gastric cancer, while its overexpression correlates with poor prognosis in non-small cell lung cancer. Additionally, PTPN3 interacts with viral proteins (e.g., HBV’s HBx and HPV’s E7), modulating viral replication and host cell transformation.
PTPN3 antibodies are essential tools for investigating its expression, subcellular localization, and interactions in normal and pathological states. They enable detection via techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies also support research into PTPN3’s therapeutic potential, as targeting its activity or interactions may offer strategies for cancer and antiviral therapies. Validated PTPN3 antibodies are critical for ensuring specificity in both basic research and clinical diagnostics.
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