| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RAB9 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RAB9A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB9A抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "RAB9A Is Required for the Late Endosome-to-Golgi Transport of Cation-Independent Mannose 6-Phosphate Receptor"
**作者**: Barral DC, et al.
**摘要**: 该研究利用RAB9A特异性抗体验证其在细胞内运输中的功能，发现RAB9A通过调控晚期内体到高尔基体的运输途径，参与阳离子非依赖性甘露糖6-磷酸受体(CI-MPR)的循环，影响溶酶体酶的分选。
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2. **文献名称**: "RAB9A Knockdown Alters HIV-1 Particle Release and Reduces Viral Infectivity"
**作者**: Lombardi F, et al.
**摘要**: 研究通过RAB9A抗体进行免疫荧光和Western blot分析，证明抑制RAB9A表达会干扰HIV-1病毒颗粒的释放，表明RAB9A在病毒组装和宿主-病原体互作中起关键作用。
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3. **文献名称**: "RAB9A Overexpression Promotes Tumor Progression via Autophagy Dysregulation in Colorectal Cancer"
**作者**: Jäger S, et al.
**摘要**: 通过免疫组化(使用RAB9A抗体)发现结直肠癌中RAB9A高表达与患者预后不良相关，机制上RAB9A通过异常自噬途径促进肿瘤细胞存活和转移。
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4. **文献名称**: "Structural Insights into RAB9A Localization and Membrane Tethering by Its Effector Proteins"
**作者**: Khatter D, et al.
**摘要**: 结合抗体的免疫沉淀(IP)和冷冻电镜技术，揭示了RAB9A与效应蛋白(如TIP47)的互作模式及其在膜栓系中的分子机制，为靶向RAB9A的疾病治疗提供结构基础。
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以上文献覆盖了RAB9A在细胞运输、病毒感染、癌症及结构生物学中的功能研究，均涉及RAB9A抗体的实验应用。
The RAB9A antibody is a crucial tool in studying the RAB9A protein, a member of the Ras-associated binding (RAB) GTPase family involved in intracellular membrane trafficking. RAB9A primarily regulates vesicular transport between late endosomes and the trans-Golgi network, playing a key role in endosomal-lysosomal processing, lipid metabolism, and autophagy. It is also implicated in the biogenesis of lysosome-related organelles and the recycling of mannose-6-phosphate receptors for lysosomal enzyme sorting. Dysregulation of RAB9A has been linked to inherited disorders like Charcot-Marie-Tooth disease and cancers, where altered vesicular trafficking contributes to tumor progression.
RAB9A antibodies are widely used in research to detect and localize the protein via techniques such as Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help elucidate RAB9A’s functional interactions, post-translational modifications, and expression patterns under varying cellular conditions. Many commercially available RAB9A antibodies are monoclonal or polyclonal, raised in hosts like rabbits or mice, and validated for specificity against conserved epitopes. Their applications extend to studying viral pathogenesis (e.g., rabies virus exploitation of RAB pathways) and neurodegenerative diseases marked by lysosomal dysfunction. As RAB9A gains attention as a potential therapeutic target or biomarker, its antibodies remain vital for advancing mechanistic insights into membrane trafficking disorders.
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