Rabbit Polyclonal RNF185 Antibody

The RNF185 (Ring Finger Protein 185) antibody is a tool used to study the RNF185 protein, a member of the RING finger family of E3 ubiquitin ligases. RNF185 is implicated in regulating cellular processes such as mitophagy, endoplasmic reticulum (ER)-associated degradation (ERAD), and the ubiquitin-proteasome system. It localizes to mitochondria and the ER, where it facilitates substrate ubiquitination, targeting damaged organelles or misfolded proteins for degradation. Research highlights its role in mitochondrial quality control through interactions with Parkin and CHIP, as well as its involvement in ER stress responses. Dysregulation of RNF185 has been linked to neurodegenerative diseases (e.g., Parkinson’s), cancer, and metabolic disorders, making it a focus for therapeutic exploration. The RNF185 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, subcellular localization, and interactions in disease models. Its specificity and reliability are critical for elucidating RNF185’s molecular mechanisms, including its E3 ligase activity and role in stress adaptation. Commercial antibodies are typically validated for cross-reactivity and performance in relevant species (e.g., human, mouse), supporting studies on mitochondrial dynamics, ER homeostasis, and disease pathology.