Rabbit Polyclonal SAMD7 Antibody

The SAMD7 antibody is designed to target the SAMD7 (Sterile Alpha Motif Domain-containing 7) protein, a member of the SAM domain-containing protein family. SAMD7 is evolutionarily conserved and plays a regulatory role in cellular processes, particularly in the context of inflammation and immune responses. It functions as a negative regulator of NF-κB signaling, a critical pathway involved in inflammation, apoptosis, and immune cell activation. SAMD7 is highly expressed in retinal pigment epithelial cells, and its dysregulation has been implicated in age-related macular degeneration (AMD), a leading cause of vision loss. Research suggests that SAMD7 may suppress pathologic angiogenesis and inflammation in the retina by modulating transcriptional activity. The SAMD7 antibody is utilized in studies to detect protein expression levels, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It serves as a vital tool for investigating SAMD7's role in ocular diseases, immune regulation, and potential therapeutic applications. Understanding SAMD7's mechanisms could advance treatments for AMD and other inflammatory disorders linked to NF-κB pathway dysfunction.