| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BCMP84; S100A15 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human S100A14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于S100A14抗体的3篇参考文献(示例格式，非真实文献)：
1. **文献名称**：*S100A14 promotes tumorigenesis and invasion via regulation of Wnt/β-catenin signaling in colorectal cancer*
**作者**：Li Y, et al.
**摘要**：研究利用S100A14特异性抗体检测其在结直肠癌组织中的表达，发现其通过激活Wnt/β-catenin通路促进肿瘤侵袭，抗体验证采用Western blot和免疫组化。
2. **文献名称**：*Development of a monoclonal antibody against human S100A14 for cancer diagnosis*
**作者**：Wang X, et al.
**摘要**：报道一种新型抗人S100A14单克隆抗体的开发与验证，该抗体在乳腺癌组织样本中显示高特异性，适用于免疫荧光和ELISA检测，为临床诊断提供工具。
3. **文献名称**：*S100A14 as a prognostic marker in oral squamous cell carcinoma: An immunohistochemical study*
**作者**：Singh R, et al.
**摘要**：通过S100A14抗体进行免疫组化分析，发现其高表达与口腔鳞癌患者预后不良相关，提示其作为潜在生物标志物的价值。
(注：以上为示例模板，实际文献需通过PubMed/Google Scholar等数据库检索获取。)
**Background of S100A14 Antibody**
S100A14. a member of the S100 calcium-binding protein family, is encoded by the *S100A14* gene located on human chromosome 1q21. This protein is implicated in diverse cellular processes, including cell proliferation, differentiation, and extracellular signaling, often through interactions with intracellular targets like p53 and extracellular matrix components. Dysregulation of S100A14 has been linked to multiple cancers, such as breast, colorectal, and oral squamous cell carcinoma, where it may act as either an oncogene or tumor suppressor depending on the tissue context.
S100A14 antibodies are essential tools for detecting and quantifying S100A14 expression in research and diagnostics. These antibodies, typically raised in rabbits or mice, are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Their specificity enables the study of S100A14’s role in tumor progression, metastasis, and its interaction with signaling pathways like EGFR and NF-κB. Recent studies also explore its potential as a biomarker for cancer prognosis or therapeutic targeting.
Despite its emerging significance, S100A14's functional mechanisms remain partially understood, necessitating further research. Reliable antibodies are critical for elucidating its dual roles in cancer and normal physiology, aiding the development of targeted therapies.
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