| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | MLN70; S100C; HEL-S-43 |
| WB Predicted band size | 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human S100A11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于S100A11抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *S100A11 promotes human pancreatic cancer cell invasion and is associated with poor prognosis in pancreatic cancer*
**作者**: Chen H et al. (2015)
**摘要**: 研究通过免疫组化(使用S100A11抗体)发现S100A11在胰腺癌组织中高表达，与患者预后不良相关，并通过调控MMP2/9促进癌细胞侵袭。
2. **文献名称**: *S100A11 is a potential therapeutic target for cutaneous squamous cell carcinoma*
**作者**: Sakaguchi M et al. (2016)
**摘要**: 利用S100A11抗体验证其在皮肤鳞癌中的高表达，发现其通过激活MAPK通路促进肿瘤增殖，提示其作为治疗靶点的潜力。
3. **文献名称**: *S100A11 interacts with annexin A2 to promote cisplatin resistance in cervical cancer cells*
**作者**: Wang L et al. (2018)
**摘要**: 研究通过免疫共沉淀(S100A11抗体)揭示S100A11与膜联蛋白A2结合，增强宫颈癌细胞对顺铂的耐药性，靶向此通路可逆转耐药。
4. **文献名称**: *Extracellular S100A11 regulates macrophage polarization and promotes tumor immunosuppression*
**作者**: Zhang Y et al. (2020)
**摘要**: 使用S100A11抗体检测肿瘤微环境中分泌型S100A11.发现其通过诱导M2型巨噬细胞极化抑制抗肿瘤免疫反应，促进肿瘤进展。
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以上文献均通过S100A11抗体探究其在不同癌症中的表达、功能及机制，涵盖基础研究和临床相关性。
S100A11. a member of the S100 calcium-binding protein family, plays diverse roles in cellular processes such as proliferation, differentiation, apoptosis, and inflammation regulation. It functions as a calcium sensor, modulating intracellular signaling pathways through interactions with target proteins like annexins and cytoskeletal components. S100A11 is implicated in cancer progression, where its expression is often dysregulated, correlating with tumor invasiveness, metastasis, and poor prognosis in cancers such as gastric, ovarian, and colorectal carcinomas. It also participates in membrane repair, calcium homeostasis, and immune responses.
Antibodies against S100A11 are critical tools for studying its expression, localization, and functional mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in both research and diagnostic applications. Commercially available S100A11 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes to ensure specificity. Validation includes testing on recombinant proteins or knockout cell lines to confirm minimal cross-reactivity with other S100 family members.
Research using S100A11 antibodies has revealed its dual role in cancer—acting as either an oncogenic promoter or tumor suppressor, depending on context. Additionally, studies explore its involvement in inflammatory diseases and cellular stress responses. Ongoing efforts focus on developing therapeutic strategies targeting S100A11 or its pathways, particularly in oncology. Reliable antibodies remain essential for unraveling its complex biology and translational potential.
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