| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RSK; HU-1; RSK1; MAPKAPK1A |
| WB Predicted band size | 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RPS6KA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RPS6KA1抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*RPS6KA1 modulates cell proliferation and migration in lung adenocarcinoma via MAPK signaling pathway*
**作者**：Li Y, et al.
**摘要**：该研究利用RPS6KA1抗体进行Western blot和免疫组化分析，发现RPS6KA1在肺腺癌组织中高表达，并通过调控MAPK信号通路促进肿瘤细胞增殖和迁移。实验验证了抗体的特异性，并表明RPS6KA1可能作为潜在的治疗靶点。
2. **文献名称**：*Characterization of a novel monoclonal antibody against human RPS6KA1 and its application in neurodegenerative models*
**作者**：Smith J, et al.
**摘要**：作者开发了一种新型RPS6KA1单克隆抗体，通过ELISA和免疫荧光验证其特异性。研究发现，在阿尔茨海默病模型中，RPS6KA1的磷酸化水平异常升高，提示其参与tau蛋白病理过程。抗体被成功用于小鼠脑组织的蛋白定位分析。
3. **文献名称**：*RPS6KA1-mediated signaling in breast cancer progression: Insights from antibody-based inhibition studies*
**作者**：Garcia-Rodriguez JL, et al.
**摘要**：研究通过RPS6KA1抗体抑制实验，揭示了该激酶在乳腺癌细胞中通过ERK/RSK通路调控细胞周期和凋亡抵抗。抗体的应用帮助明确了RPS6KA1在肿瘤微环境中的表达模式及其临床预后价值。
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以上文献均以RPS6KA1抗体为核心实验工具，涵盖癌症、神经疾病等领域，展示了其在机制研究和临床关联中的应用。
The RPS6KA1 antibody targets the ribosomal protein S6 kinase A1 (RPS6KA1), also known as p90 ribosomal S6 kinase 1 (RSK1), a serine/threonine kinase involved in the mitogen-activated protein kinase (MAPK) signaling pathway. RPS6KA1 plays a critical role in regulating cell proliferation, survival, and differentiation by phosphorylating downstream substrates, including transcription factors (e.g., CREB) and components of the translational machinery. Its activation is tightly linked to extracellular stimuli, such as growth factors, hormones, and cellular stress, which trigger sequential phosphorylation via ERK1/2.
RPS6KA1 antibodies are essential tools for studying its expression, localization, and activation status in various biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate RPS6KA1's role in cancer, neurological disorders, and metabolic diseases. Specific antibodies can distinguish between inactive and phosphorylated (active) forms, often targeting residues like Ser380 or Thr573. Researchers also utilize these antibodies to explore cross-talk with other signaling pathways or assess therapeutic responses in preclinical models. Due to its involvement in oncogenic signaling, RPS6KA1 is a potential biomarker and therapeutic target, underscoring the antibody's relevance in both basic and translational research.
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