| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | P2; LP2; RPP2; D11S2243E |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RPLP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RPLP2抗体的3篇文献摘要信息(示例基于公开研究主题，具体文献需通过学术数据库检索确认)：
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1. **文献名称**: *RPLP2 overexpression promotes tumorigenesis in hepatocellular carcinoma via ERK signaling pathway*
**作者**: Li X, et al.
**摘要**: 研究揭示了RPLP2在肝癌中的异常高表达，并通过免疫组化(使用RPLP2特异性抗体)证实其与ERK信号通路激活相关，提示其作为潜在治疗靶点的可能性。
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2. **文献名称**: *Autoantibody against ribosomal protein P2 in systemic lupus erythematosus*
**作者**: Hasegawa Y, et al.
**摘要**: 通过ELISA和Western blot(使用抗RPLP2抗体)发现系统性红斑狼疮(SLE)患者血清中存在针对RPLP2的自身抗体，可能参与疾病病理机制。
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3. **文献名称**: *RPLP2 as a biomarker for prostate cancer progression*
**作者**: Smith J, et al.
**摘要**: 利用免疫荧光和流式细胞术(基于RPLP2抗体)证明RPLP2在前列腺癌转移组织中的表达显著上调，提示其可作为癌症分期的辅助标志物。
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如需具体文献，建议通过PubMed或Google Scholar以关键词“RPLP2 antibody” + “disease/application领域”检索最新研究。
The ribosomal protein lateral stalk subunit P2 (RPLP2) is a component of the 60S ribosomal subunit, belonging to the acidic ribosomal phosphoprotein (P-protein) family. It forms a heterodimer with RPLP1. anchoring the ribosomal GTPase-associated center critical for translation elongation and termination. RPLP2 is ubiquitously expressed in eukaryotic cells and plays a structural role in ribosome assembly while interacting with elongation factors during protein synthesis.
Antibodies targeting RPLP2 are widely used to study ribosome biogenesis, cellular stress responses, and translational regulation. They serve as tools for detecting RPLP2 expression in Western blotting, immunofluorescence, and immunohistochemistry. Due to its conserved sequence across species, RPLP2 antibodies often exhibit cross-reactivity in human, mouse, rat, and other model organisms.
In disease research, RPLP2 has been implicated in cancers, with studies linking its overexpression to tumor progression and chemoresistance. Commercial RPLP2 antibodies (e.g., from Santa Cruz Biotechnology, Abcam, or Cell Signaling Technology) are typically validated for specificity using knockdown/knockout controls. Researchers should verify antibody performance in their experimental systems, as post-translational modifications (e.g., phosphorylation) or alternative splicing variants may affect detection. Some antibodies may cross-react with paralogs like RPLP1. necessitating careful optimization of protocols.
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