| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | C21; DC42; IRA1; TBLR1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TBL1XR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TBL1XR1抗体的3篇参考文献示例(文献信息为模拟概括，实际文献需通过数据库查询确认)：
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1. **文献名称**: *TBL1XR1 promotes Wnt/β-catenin signaling and chemoresistance in colorectal cancer*
**作者**: Zhang Y, et al.
**摘要**: 研究通过Western blot和免疫组化(使用TBL1XR1抗体)发现，TBL1XR1通过增强Wnt通路活性导致结直肠癌化疗耐药，提示其作为治疗靶点的潜力。
2. **文献名称**: *TBL1XR1 mutations in autism spectrum disorder and intellectual disability*
**作者**: Sáez C, et al.
**摘要**: 利用TBL1XR1特异性抗体进行蛋白表达分析，发现该基因突变导致神经发育异常，可能与自闭症谱系障碍及智力障碍的病理机制相关。
3. **文献名称**: *Role of TBL1XR1 in regulating macrophage polarization during inflammation*
**作者**: Li H, et al.
**摘要**: 研究通过siRNA沉默及抗体介导的蛋白检测，证实TBL1XR1调控巨噬细胞M1/M2极化，影响炎症反应进程。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“TBL1XR1 antibody”或“TBL1XR1 function”获取最新研究。
The TBL1XR1 antibody is a research tool designed to detect Transducin Beta-Like 1 X-Linked Receptor 1 (TBL1XR1), a protein encoded by the *TBL1XR1* gene. TBL1XR1 is a core component of the nuclear receptor corepressor (N-CoR)/histone deacetylase 3 (HDAC3) complex, which regulates transcriptional repression and chromatin remodeling. Structurally, TBL1XR1 contains WD40 repeat domains that mediate protein-protein interactions, facilitating its role in nuclear receptor signaling and Wnt/β-catenin pathway modulation.
Antibodies targeting TBL1XR1 are widely used in studies investigating its expression patterns, subcellular localization, and functional interactions. They are validated in applications like Western blotting, immunoprecipitation, and immunofluorescence. Research has linked TBL1XR1 dysregulation to various diseases, including cancers (e.g., glioblastoma, breast cancer), neurodevelopmental disorders (e.g., autism, intellectual disability), and chemotherapy resistance. Epitope-tagged or monoclonal TBL1XR1 antibodies are often employed to ensure specificity, with validation via knockout cell lines or siRNA knockdown.
These antibodies have advanced understanding of TBL1XR1’s dual roles as a transcriptional coregulator and oncogenic driver, highlighting its potential as a biomarker or therapeutic target. Studies also explore its involvement in developmental pathways and drug response mechanisms, underscoring its broad biological relevance.
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