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Rabbit Polyclonal TRIP6 Antibody

  • 中文名： TRIP6抗体
  • 别    名： OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
货号: IPDX08912
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/10000 Human,Mouse,Rat

产品详情

AliasesHM5
Entrez GeneID1133
clone7E5H11
WB Predicted band size42.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CHRM5 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇关于TRIP6抗体的代表性文献摘要概览(注：文献为模拟示例，实际引用需核实PMID或DOI)：

1. **"TRIP6 regulates integrin α5β1 trafficking and promotes cancer cell invasion"**

- **作者**: Smith A, et al.

- **摘要**: 研究利用TRIP6特异性抗体进行免疫沉淀和免疫荧光实验，揭示了TRIP6通过调控整合素α5β1的内吞循环，增强乳腺癌细胞迁移和侵袭的分子机制。

2. **"The role of TRIP6 in Hippo-YAP signaling and cell proliferation"**

- **作者**: Chen L, et al.

- **摘要**: 通过Western blot和免疫组化分析，发现TRIP6抗体检测到的蛋白表达水平与YAP活性呈正相关，表明TRIP6通过抑制LATS1激酶促进YAP入核驱动肝癌进展。

3. **"TRIP6 interacts with LPA receptors to mediate lysophosphatidic acid-induced cell migration"**

- **作者**: Wang Y, et al.

- **摘要**: 利用TRIP6抗体进行共聚焦显微镜观察，证实TRIP6与溶血磷脂酸受体(LPAR)结合并激活RhoA信号通路，促进卵巢癌细胞定向迁移。

如需具体文献，建议在PubMed或Google Scholar中以“TRIP6 antibody”及“TRIP6 function”为关键词检索，并筛选涉及抗体实验(如ChIP、IP、IHC等)的论文。

背景信息

The TRIP6 (Thyroid Receptor Interacting Protein 6) antibody is a tool used to study the biological functions of TRIP6. a multifunctional adaptor protein belonging to the LIM domain-containing protein family. TRIP6. also known as ZRP-1 (zyxin-related protein 1), is involved in diverse cellular processes, including cell adhesion, migration, proliferation, and signal transduction. It interacts with components of the cytoskeleton, nuclear receptors (e.g., thyroid hormone receptor), and signaling pathways (e.g., integrin, NF-κB, and Hippo pathways), acting as a molecular scaffold to regulate downstream effectors. TRIP6 is implicated in cancer progression, inflammation, and cardiovascular diseases, with studies highlighting its overexpression in malignancies like breast and ovarian cancers. The TRIP6 antibody, typically produced in rabbits or mice, enables detection and localization of TRIP6 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its specificity is validated using knockout controls or siRNA-mediated knockdowns. Research utilizing this antibody has advanced understanding of TRIP6's role in tumor metastasis, mechanotransduction, and transcriptional regulation, positioning it as a potential therapeutic or diagnostic target. Commercial TRIP6 antibodies are widely available, supporting both basic research and clinical investigations.

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