Rabbit Polyclonal TRIP6 Antibody

The TRIP6 (Thyroid Receptor Interacting Protein 6) antibody is a tool used to study the biological functions of TRIP6. a multifunctional adaptor protein belonging to the LIM domain-containing protein family. TRIP6. also known as ZRP-1 (zyxin-related protein 1), is involved in diverse cellular processes, including cell adhesion, migration, proliferation, and signal transduction. It interacts with components of the cytoskeleton, nuclear receptors (e.g., thyroid hormone receptor), and signaling pathways (e.g., integrin, NF-κB, and Hippo pathways), acting as a molecular scaffold to regulate downstream effectors. TRIP6 is implicated in cancer progression, inflammation, and cardiovascular diseases, with studies highlighting its overexpression in malignancies like breast and ovarian cancers. The TRIP6 antibody, typically produced in rabbits or mice, enables detection and localization of TRIP6 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its specificity is validated using knockout controls or siRNA-mediated knockdowns. Research utilizing this antibody has advanced understanding of TRIP6's role in tumor metastasis, mechanotransduction, and transcriptional regulation, positioning it as a potential therapeutic or diagnostic target. Commercial TRIP6 antibodies are widely available, supporting both basic research and clinical investigations.