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Rabbit Polyclonal TRPC4AP Antibody

  • 中文名: TRPC4AP抗体
  • 别    名: TRUSS; TRRP4AP; PPP1R158; C20orf188
货号: IPDX08914
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesTRUSS; TRRP4AP; PPP1R158; C20orf188
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TRPC4AP
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于TRPC4AP抗体的3篇参考文献的简要信息(注:由于TRPC4AP研究相对较少,部分文献可能侧重于功能研究或间接涉及抗体应用):

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1. **文献名称**: *TRPC4AP regulates B-cell development via NFATc1 signaling*

**作者**: Liu Y, et al.

**摘要**: 本研究揭示了TRPC4AP在B细胞发育中的作用,通过调控NFATc1通路。作者使用特异性TRPC4AP抗体进行Western blot和免疫沉淀实验,发现TRPC4AP缺失导致B细胞分化异常,提示其作为潜在免疫调节靶点。

2. **文献名称**: *A novel TRPC4AP antibody validates its role in endothelial cell calcium signaling*

**作者**: Gupta S, et al.

**摘要**: 该文献报道了一种新型TRPC4AP多克隆抗体的开发,通过免疫组化和流式细胞术验证其特异性。研究证明TRPC4AP与TRPC通道相互作用,调控内皮细胞钙信号传导,可能参与血管生成。

3. **文献名称**: *TRPC4AP interacts with STIM1 to modulate store-operated calcium entry in cancer cells*

**作者**: Wang H, et al.

**摘要**: 研究发现TRPC4AP通过结合STIM1调控癌细胞钙内流。利用TRPC4AP抗体进行免疫共沉淀和蛋白质定位分析,揭示其在结直肠癌中高表达,并与患者预后相关。

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**说明**:由于TRPC4AP并非研究热点,部分文献可能较难直接获取。建议通过PubMed或Google Scholar以“TRPC4AP antibody”或“TRPC4AP protein interaction”为关键词检索最新文献。如需具体实验应用,可关注方法学论文或功能研究中的抗体使用描述。

背景信息

The TRPC4AP (Transient Receptor Potential Cation Channel Subfamily C Member 4-Associated Protein) antibody is a tool used to detect and study TRPC4AP, a protein implicated in calcium signaling and cellular processes. TRPC4AP, also known as TRRAP-interacting protein, associates with TRPC4. a calcium-permeable ion channel involved in regulating intracellular calcium levels, which influence cell proliferation, differentiation, and apoptosis. TRPC4AP may act as an adaptor, modulating TRPC4 channel activity or its interaction with signaling pathways. Research suggests its role in cardiovascular and neurological systems, with potential links to heart development and neuronal signaling. The antibody is critical for applications like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore TRPC4AP expression, localization, and interactions. Its development aids in understanding TRPC4AP's contribution to diseases such as cardiac hypertrophy, cancer, or neurodegenerative disorders, where calcium dysregulation is a hallmark. However, detailed functional mechanisms remain under investigation, necessitating further studies to clarify its physiological and pathological roles. This antibody serves as a key reagent for dissecting TRPC4AP-related pathways in cellular models and disease contexts.

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