Rabbit Polyclonal WDR5 Antibody

The WDR5 (WD Repeat Domain 5) antibody is a key tool for studying the multifaceted roles of the WDR5 protein, a conserved component of chromatin-modifying complexes. WDR5. part of the WD40-repeat protein family, serves as a scaffold in epigenetic regulation, notably within the MLL/SET histone methyltransferase complexes that catalyze H3K4 methylation—a hallmark of active gene promoters. It also interacts with MYC, RbBP5. and other factors, influencing processes like stem cell maintenance, differentiation, and cancer progression. Antibodies targeting WDR5 enable researchers to investigate its localization, protein-protein interactions (via co-immunoprecipitation), and chromatin occupancy (through ChIP-seq). They are critical in dissecting WDR5's dual roles in gene activation (via histone modification) and potential oncogenic functions. Commercially available WDR5 antibodies are typically developed in hosts like rabbit or mouse, with validation methods including knockout cell controls or peptide blocking to ensure specificity. These reagents are widely used in cancer biology, developmental studies, and drug discovery, particularly for targeting WDR5-dependent pathways in malignancies. Recent studies also explore its non-canonical roles in cytoskeletal regulation, expanding its therapeutic relevance.