Rabbit Polyclonal VPS37D Antibody

The VPS37D antibody is a research tool designed to detect and study the VPS37D protein, a component of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. VPS37D, one of four mammalian paralogs (VPS37A-D), is part of the ESCRT-I complex, which plays critical roles in membrane remodeling processes such as multivesicular body (MVB) formation, viral budding, cytokinesis, and plasma membrane repair. This protein is implicated in ubiquitin-dependent cargo sorting and membrane scission events. Antibodies targeting VPS37D are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in cellular pathways. Researchers utilize these antibodies to explore VPS37D's involvement in diseases linked to ESCRT dysfunction, including cancer, neurodegenerative disorders, and viral infections. Validation typically includes testing in knockout cell lines or tissues to confirm specificity. Due to functional redundancy among ESCRT-I subunits, studies using VPS37D antibodies often focus on distinguishing its unique roles from other VPS37 isoforms. Commercial availability varies, with some antibodies being species-specific (e.g., human, mouse, or Drosophila). Recent studies highlight its potential role in regulating epidermal growth factor receptor (EGFR) trafficking and autophagy, making it relevant for therapeutic target discovery.