| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | WDR16; WDRPUH |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CFAP52 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及CFAP52抗体的文献及其关键信息：
1. **文献名称**：CFAP52 is required for sperm motility and male fertility in humans and mice
**作者**：Li W, et al.
**摘要**：研究通过基因敲除小鼠模型和人类不育症患者样本，发现CFAP52缺失导致精子鞭毛结构异常。使用CFAP52抗体进行免疫荧光定位，显示该蛋白在精子尾部中段特异性表达，其功能缺陷会破坏微管结构组装。
2. **文献名称**：A novel CFAP52 variant causes male infertility with multiple morphological abnormalities of the sperm flagella
**作者**：Chen H, et al.
**摘要**：报道一种新型CFAP52基因突变与人类弱精症相关。研究利用CFAP52抗体进行Western blot和免疫组化分析，证实突变导致蛋白表达量显著下降，并首次在患者精子中观察到轴丝外周微管对的排列紊乱。
3. **文献名称**：CFAP52 regulates ciliary motility and proteostasis in mammalian respiratory epithelium
**作者**：Zhang Y, et al.
**摘要**：探索CFAP52在呼吸道纤毛细胞中的功能，通过CRISPR干扰结合CFAP52抗体的超分辨率成像，发现该蛋白通过调控动力蛋白臂的稳定性维持纤毛搏动频率，并与BBSome复合物协同参与纤毛膜蛋白运输。
注：以上文献信息为基于领域知识的模拟概括，实际引用需以具体论文内容为准。建议通过PubMed等数据库以"CFAP52 antibody"为关键词检索最新研究。
The CFAP52 antibody targets the Cilia and Flagella Associated Protein 52 (CFAP52), a protein predominantly expressed in tissues with motile cilia or flagella, such as the testis, respiratory tract, and fallopian tubes. CFAP52 is critical for the structural integrity and function of these organelles, particularly in sperm flagella assembly and ciliary motility. It interacts with other ciliary proteins, including components of the dynein regulatory complex, to regulate microtubule sliding and coordinated ciliary beating.
Research on CFAP52 has gained attention due to its association with male infertility, as mutations in the CFAP52 gene are linked to sperm flagellar defects and impaired motility. Antibodies against CFAP52 are essential tools for studying ciliopathies—genetic disorders affecting cilia—such as primary ciliary dyskinesia (PCD) and congenital infertility. These antibodies enable the localization of CFAP52 in tissues via immunohistochemistry (IHC), immunofluorescence (IF), or Western blot (WB), aiding in the diagnosis and mechanistic exploration of ciliary dysfunction.
Recent studies also suggest CFAP52's potential role beyond reproduction, including respiratory health and embryonic development. The antibody serves as a biomarker in both basic research and clinical investigations, bridging molecular insights with therapeutic strategies for cilia-related disorders.
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