Rabbit Polyclonal DCAF7 Antibody

The DCAF7 (DDB1 and CUL4-associated factor 7) antibody is a tool used to study the role of DCAF7. a scaffold protein involved in cellular signaling and protein degradation. DCAF7. also known as WDR68. contains WD40 repeats that mediate protein-protein interactions. It serves as an adaptor component of the CRL4-DDB1 E3 ubiquitin ligase complex, which targets substrates for proteasomal degradation. DCAF7 is notably linked to the Wnt/β-catenin signaling pathway, where it interacts with Dishevelled (DVL) proteins to regulate embryonic development, cell polarity, and tissue homeostasis. Dysregulation of DCAF7 has been implicated in cancers (e.g., hepatocellular carcinoma, colorectal cancer) and neurodevelopmental disorders like autism spectrum disorders. Researchers use DCAF7 antibodies in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, subcellular localization, and interactions with partners like DVL or components of the CRL4 complex. These studies aim to elucidate DCAF7's role in disease mechanisms, particularly its dual functions in protein stability and developmental signaling, offering potential insights into therapeutic targeting.