| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | S21; HLDF |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RPS21抗体的3篇参考文献示例(注：内容为模拟概括，建议通过学术数据库核实最新文献)：
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1. **文献名称**：*RPS21 promotes hepatocellular carcinoma progression via MDM2-mediated p53 ubiquitination*
**作者**：Wang, X. et al.
**摘要**：研究利用RPS21抗体通过免疫印迹和免疫组化技术，发现RPS21在肝癌组织中高表达，并通过调控MDM2-p53通路促进肿瘤增殖和转移，提示其作为潜在治疗靶点。
2. **文献名称**：*Development and validation of a monoclonal antibody specific for human RPS21*
**作者**：Zhang, Y. et al.
**摘要**：报道了一种高特异性抗RPS21单克隆抗体的开发，通过ELISA、Western blot和免疫荧光验证其在多种细胞模型中的应用，为RPS21功能研究提供可靠工具。
3. **文献名称**：*RPS21 interacts with HIV-1 Rev protein to facilitate viral replication*
**作者**：Chen, L. et al.
**摘要**：研究利用RPS21抗体进行免疫共沉淀实验，揭示RPS21与HIV-1 Rev蛋白相互作用，促进病毒RNA核输出，为抗病毒治疗提供新机制。
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**建议**：可通过PubMed或Google Scholar搜索关键词“RPS21 antibody”、“RPS21 biomarker”或“RPS21 ribosome”获取最新文献，关注其在癌症、病毒感染或抗体开发中的应用研究。
The RPS21 antibody is a valuable tool for investigating the function and expression of ribosomal protein S21 (RPS21), a component of the 40S ribosomal subunit. RPS21 plays a critical role in mRNA translation, ribosome biogenesis, and has been implicated in extraribosomal functions, including cell cycle regulation, apoptosis, and DNA repair. Studies suggest its dysregulation may contribute to cancer progression, viral infection responses, and neurodegenerative disorders.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect RPS21 expression levels, subcellular localization, and interactions in various biological samples. It is typically produced in hosts such as rabbits or mice, targeting specific epitopes of human RPS21. with cross-reactivity often validated in model organisms like mice and rats.
Quality control includes validation via siRNA knockdown, peptide blocking assays, or recombinant protein recognition to ensure specificity. Researchers utilize the RPS21 antibody to explore its role in diseases; for example, elevated RPS21 levels correlate with poor prognosis in cancers like hepatocellular carcinoma, while reduced expression may link to neurodegenerative mechanisms. Its application aids in elucidating ribosome-related pathologies and potential therapeutic targets.
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