| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BFGF; FGFB; HBGF-2; FGF2 |
| Entrez GeneID | 2247 |
| clone | 2H5G2C11 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of FGF2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于TIGD5抗体的3篇参考文献示例(注：以下内容为模拟概括，实际文献需根据具体数据库检索)：
1. **文献名称**：*TIGD5 promotes hepatocellular carcinoma progression by inducing cell proliferation and invasion*
**作者**：Li X, Zhang Y, et al.
**摘要**：本研究利用TIGD5抗体通过Western blot和免疫组化技术，发现TIGD5在肝癌组织中高表达，并通过调控Wnt/β-catenin信号通路促进肿瘤细胞增殖和转移。
2. **文献名称**：*The role of TIGD5 in DNA damage repair and its interaction with PARP1*
**作者**：Wang C, Liu H, et al.
**摘要**：通过免疫沉淀(IP)和TIGD5抗体的应用，本文揭示TIGD5与PARP1蛋白相互作用，参与DNA损伤修复过程，沉默TIGD5可增强癌细胞对化疗的敏感性。
3. **文献名称**：*TIGD5 as a novel biomarker for colorectal cancer diagnosis and prognosis*
**作者**：Chen J, Zhou M, et al.
**摘要**：利用TIGD5抗体进行组织芯片分析，发现TIGD5在结直肠癌中显著高表达，且与患者生存率负相关，提示其作为潜在诊断标志物的价值。
4. **文献名称**：*TIGD5 regulates breast cancer stemness via modulating Notch signaling*
**作者**：Kim S, Park EJ, et al.
**摘要**：通过TIGD5抗体的免疫荧光染色，研究证实TIGD5通过激活Notch通路维持乳腺癌干细胞特性，靶向TIGD5可抑制肿瘤复发。
如需具体文献，建议在PubMed或Google Scholar中检索关键词“TIGD5 antibody”或“TIGD5 function”。
The TIGD5 antibody is designed to target TIGD5 (Tigger Transposable Element-Derived Protein 5), a member of the Tigger-derived protein family, which is evolutionarily linked to transposon-derived genes. TIGD5 is a putative DNA-binding protein implicated in chromatin remodeling and transcriptional regulation, though its precise biological functions remain under investigation. It contains a conserved Tigger-derived domain, suggesting potential roles in genome stability or epigenetic modulation. Aberrant TIGD5 expression has been observed in certain cancers and neurological disorders, sparking interest in its involvement in disease mechanisms.
TIGD5 antibodies are primarily used in research to detect and quantify TIGD5 protein levels in tissues or cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically developed in hosts such as rabbits or mice, with monoclonal and polyclonal variants available. Validation often includes knockout cell lines to confirm specificity. Researchers employ TIGD5 antibodies to explore its localization, interaction partners, and expression patterns under physiological or pathological conditions. Recent studies have linked TIGD5 to pathways involving DNA repair and cellular differentiation, though further work is needed to clarify its regulatory networks. Commercial TIGD5 antibodies often cite applications in cancer biology and neurodevelopmental research, with optimized protocols for cross-species reactivity (e.g., human, mouse). Proper controls are essential due to potential cross-reactivity with other Tigger family proteins.
×
