| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | CGI-134; S18mt-c; MRPS18-1; mrps18-c; MRP-S18-1; MRP-S18-c |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于MRPS18C抗体的3篇示例参考文献(注：文献信息为示例性概括，非真实存在)：
1. **"Mitochondrial ribosomal protein S18C (MRPS18C) antibody development and validation in human tissues"**
- 作者：Zhang L, et al.
- 摘要：本研究报道了一种针对MRPS18C蛋白的高特异性多克隆抗体的开发，通过免疫印迹(Western blot)和免疫组化验证了其在多种人类组织中的表达，并证实其在癌症细胞系中线粒体定位的特异性。
2. **"MRPS18C modulates apoptosis via Bcl-2 family interaction: Insights from antibody-mediated knockdown experiments"**
- 作者：Kim S, et al.
- 摘要：通过使用靶向MRPS18C的小干扰RNA和特异性抗体，研究发现该蛋白通过调控Bcl-2家族蛋白活性影响线粒体凋亡通路，揭示了其在结肠癌细胞耐药性中的潜在作用。
3. **"Prognostic significance of MRPS18C overexpression in breast cancer detected by a novel monoclonal antibody"**
- 作者：Wang Y, et al.
- 摘要：文章描述了一种新型MRPS18C单克隆抗体的开发，并用于分析乳腺癌临床样本。结果显示，MRPS18C的高表达与患者生存率降低显著相关，提示其作为乳腺癌预后标志物的潜力。
(注：若需真实文献，建议通过PubMed或Google Scholar以“MRPS18C antibody”为关键词检索，或补充具体研究背景进一步筛选。)
The mitochondrial ribosomal protein S18C (MRPS18C) is a component of the small subunit (28S) of the mitochondrial ribosome, which plays a critical role in mitochondrial protein synthesis. Encoded by the nuclear gene MRPS18C, this protein is essential for assembling the ribosomal machinery responsible for translating mitochondrial DNA-encoded mRNAs, particularly those involved in oxidative phosphorylation (OXPHOS). Dysregulation of mitochondrial ribosomes is linked to metabolic disorders, neurodegenerative diseases, and cancer.
MRPS18C-specific antibodies are valuable tools for studying mitochondrial translation mechanisms, ribosome biogenesis, and mitochondrial dysfunction. Researchers utilize these antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect MRPS18C expression levels, subcellular localization, and interactions with other ribosomal proteins or regulatory factors. Studies suggest that MRPS18C may influence cellular proliferation and apoptosis, with altered expression observed in certain cancers, though its precise oncogenic or tumor-suppressive role remains under investigation. Additionally, MRPS18C mutations or deficiencies have been associated with rare mitochondrial disorders characterized by impaired energy production.
Developing high-specificity MRPS18C antibodies requires careful validation to avoid cross-reactivity with homologous cytosolic ribosomal proteins. Current research focuses on elucidating its structural contributions to ribosome assembly and exploring therapeutic targeting in mitochondrial diseases or cancer.
×
