Rabbit Polyclonal ACBD4 Antibody

The ACBD4 (Acyl-CoA-binding domain-containing protein 4) antibody is a tool used to study the function and localization of the ACBD4 protein, a member of the ACBD family implicated in lipid metabolism and intracellular membrane trafficking. ACBD4 contains a conserved acyl-CoA-binding domain, suggesting roles in binding acyl-CoA esters, which are critical intermediates in lipid biosynthesis and signaling. While its paralog ACBD3 is well-characterized in Golgi integrity and viral replication, ACBD4 remains less understood. Current research indicates ACBD4 may localize to mitochondria-associated membranes (MAMs), potentially facilitating lipid exchange between organelles or modulating mitochondrial function. The ACBD4 antibody is primarily utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression patterns in tissues or cultured cells. Studies employing this antibody could shed light on ACBD4's involvement in metabolic disorders, neurodegenerative diseases, or cancer, where lipid dysregulation is prevalent. However, limited commercial availability and a lack of extensive functional data pose challenges. Validating antibody specificity through knockout controls remains essential, as cross-reactivity with other ACBD proteins is a concern. Further research is needed to clarify ACBD4's precise biological roles and therapeutic relevance.